Ernst Knobil, PhD Papers

knobil096-color

Manuscript Collection No. 96


TABLE OF CONTENTS

Overview of the Collection

Repository: Houston Academy of Medicine-Texas Medical Center Library, John P. McGovern Historical Collections and Research Center, 1133 John Freeman Blvd. Houston, Texas 77030
Creator: Knobil, Ernst (1926-2000)
Title: Ernst Knobil PhD Papers
Dates: 1942-2000
Quantity: 71 cubic feet
Abstract: Ernst Knobil, PhD was a world renowned physiologist whose work was seminal in many areas of endocrinology. Dr. Knobil was on the faculty of the Harvard Medical School, Chairman of the Department of Physiology at the University of Pittsburgh School of Medicine, and Dean of the University of Texas Medical School at Houston. He maintained an active research laboratory from 1951 to 1997. This collection contains data notebooks from his laboratories; information about the funding support he received from various sources, including the National Institutes of Health; information about his Deanship and other appointments; lectures and material for classes he taught; significant resources on his activities with professional organizations, such as the National Academy of Sciences and the American Physiology Society; correspondence with a wide range of national and international scientists; reprints and/or manuscripts of his published material; and biographical information about his education. This collection provides a comprehensive overview of work of an important and distinguished biomedical scientist and academic of the latter half of the twentieth century.
Identification: MS 96
Language: The records are in English, with some correspondence in French.

Biographical Note

Dr. Ernst Knobil was a leader and pioneer in many areas of endocrinology, including growth and reproduction. Dr. Knobil’s classic contributions include the species-specific effects of Growth Hormone (GH), a model for positive and negative estrogen feedback control of the menstrual cycle, and elucidation of the hypothalamic Gonadotrpin-Releasing Hormone (GnRH) pulse generator. His discovery that pulsatile GnRH stimulates Luteinizing Hormone (LH) secretion, altered the field of reproductive endocrinology. This observation also unmasked a pivotal role for pulsatile secretion as a mechanism of hormonal control.

The son of Austrian parents, Dr. Knobil was born in Berlin, Germany on September 20, 1926. The Knobil family moved to Paris in the early 1930’s. When the Germans invaded Paris in 1940, the family emigrated to New York City where he attended high school.

At the age of 15, he entered the New York State College of Agriculture at Cornell in 1942. He chose Animal Science as his major due to interests developed from time spent on farms in France during the summers, and from attending the Kinderhook Farm Camp after moving to the United States.

Upon graduating from Cornell in 1948 (including a 2 year interruption of service in the US Army), he entered graduate school in zoology where he worked in the laboratory of Professor Sanuel L. Leonard. After completing his PhD, Dr. Knobil accepted a post-doctoral position with Roy O. Greep at the Harvard School of Dental Medicine from 1951 to 1953. While a fellow, he assumed Greep’s teaching duties in endocrinology and rapidly gained recognition as a gifted and scholarly teacher.

In 1953 he was appointed Instructor in the Physiology Department of the Harvard Medical School. In 1957, he was promoted to Assistant Professor after having been selected by Harvard Medical School for the prestigious Markle Scholar in Academic Medicine for the years 1956-1961.

From 1961-1981 he was the Richard Beatty Mellon Professor of Physiology, Chairman of the Department of Physiology and the Director of the Center for Research in Primate Reproduction at the University of Pittsburgh Medical School

Dr. Knobil accepted the Deanship of the University of Texas Medical School at Houston in 1981. From 1981 on he was also the H. Wayne Hightower Professor in the Medical Sciences and Director of the Laboratory of the Laboratory for Neuroendocrinology at the University of Texas-Houston Health Science Center – Medical School. The Laboratory closed in 1997. More than 80 fellows and students studied in his laboratories in Boston, Pittsburgh and Houston. In 1989 he was named an Ashbel Smith Professor, the University of Texas Health Science Center.

Among the many awards, Dr. Knobil received were the highest ones awarded by the Society for the Study of Reproduction (Carl G. Hartman Award, 1983), The Endocrine Society (Fred Conrad Koch Award, 1982), and the American Physiological Society (Walter B. Cannon Memorial Lecture, 1997). He was elected to numerous positions of leadership including the Presidencies of The Endocrine Society (1976), the American Physiological Society (1979), and the International Society of Endocrinology (1984-1988). He was a member of many U.S. and foreign scientific societies’ review boards, NIH study sections, and the editorial broads of numerous scientific journals.

Dr. Knobil was a member of the U.S. National Academy of Science (1986), the American Academy of Arts and Sciences, a foreign associate of the French Academy of Science, the Italian National Academy of Science, and the Belgian Royal Academy of Medicine. He received several honorary degrees among them ones from the University of Bordeaux (1980), the Medical College of Wisconsin (1983), the University of Liege (1994), and the University of Milan (2000).

In addition to being the author of 217 scientific papears, he was the editor of several reference books in endocrinology and reproduction, including The Handbook of Physiology (1974), The Physiology of Reproduction (1988, 1994), and The Encyclopedia of Reproduction (1998).

Dr. Knobil died April 13, 2000 in Houston Texas. He was survived by his wife of 40 years, Dr. Julane Hotchkiss Knobil, three sons, one daughter and four grandchildren.

Adapted from the Endocrine Reviews 22(6): 721-723, 2001.

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Scope and Contents

The notebooks from Dr. Knobil’s research laboratories comprise the largest series (X). General Files, Series IV, contains material including correspondence, lectures and speeches from the early 1980s to 2000. It was retained in the alphabetical order it was received. Material in Series II was labeled Harvard and deals primarily with Dr. Knobil’s tenure at Harvard University in the 1950s. Material about his Deanship of the University of Texas Medical School at Houston can be found in Series III and IV.

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Arrangement

The papers are kept in the same series which they were kept by Dr. Knobil and donated to the Archive.

Series

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Index Terms

 

This record series is indexed under the following controlled access subject terms.

Persons

Bulger, Roger J.
Greep, Roy O.
Hightower, H. Wayne
Hotchkiss, Julane
Neill, Jimmy D.

Corporate

Academic Press
American Academy of Arts and Sciences
American Physiological Society (1887- )
Association of American Medical Colleges
Cornell University
Harvard Medical School
International Society of Endocrinology
International Union of Physiological Sciences
John and Mary R. Markle Foundation
Lippincott-Raven Publishers
National Academy of Sciences (U.S.)
National Institutes of Health (U.S.)
Raven Press
Society for Endocrinology
University of Pittsburgh. School of Medicine. Dept. of Physiology
University of Texas Health Science Center-Houston
University of Texas Medical School at Houston
Yerkes Regional Primate Research Center

Subjects

Academic Medical Centers
Endocrinology
Hormones
Models, Animal
Neuroendocrinology
Physiology
Reproductive Medicine
Research Support

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Administrative Information

Custodial History

These papers were a gift from Dr. Ernst Knobil and Dr. Julane Hotchkiss Knobil.

Preferred Citation

Ernst Knobil, PhD Papers, Manuscript Collection No. 96, John P. McGovern Historical Collections and Research Center, Houston Academy of Medicine-Texas Medical Center Library

Processing Information

The collection was refoldered into archival folders and boxes. Paperclips were removed, but staples, unless deteriorated, were retained. Curriculum vita of other people, reprints of other people’s work, itineraries, agendas, and minutes were discarded unless Dr. Knobil held the meetings or commented directly on the items.

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Bibliography

  • 1. Leonard, S.L. and E. Knobil. B-glucuronidase activity in the rat uterus. Endocrinology 7:331-337, 1950.
  • 2. Knobil, E. The relation of some steroid hormones to beta-glucuronidase activity. Endocrinology 50:16-28, 1952.
  • 3. Greep, R.O., E. Knobil, F.G. Hofmann and T.L. Jones. Adrenal cortical insufficiency in the rhesus monkey. Endocrinology 50:664-676, 1952.
  • 4. Knobil, E., F.G. Hofmann and R.O. Greep. Effects on large doses of deoxycorticosterone acetate, cortisone acetate and ACTH in intact rhesus monkeys. Proc. Sec. Exp. Biol. Med. 82:691-694, 1953.
  • 5. Knobil, E. and W.L. Caton. The effect of hypophysectomy on fetal and placental growth in the rat. Endocrinology 53:198-201, 1953.
  • 6. Knobil, E., F.G. Hofmann and R.O. Greep. Failure of methyl-androstenediol to prevent compensatory atrophy of the adrenal in the rhesus monkey. Endocrinology 53:242-244, 1953.
  • 7.Knobil, E. Effects of hypophysectomy, ACTH, cortisone and estradiol on the beta-glucuronidase activity of adrenal gland in the rat. Proc. Soc. Exp. Biol. Med. 83:769-770, 1953.
  • 8. Knobil, E., F.G. Hofmann and R.O. Greep. Effects of cortisone acetate and 17-hydroxycorticosterone acetate on the adrenalectomized rhesus monkey. Am. J. Physiol. 178:351-360, 1954.
  • 9. Hofmann, F.G., E. Knobil and R.O. Greep. Effects of saline on the adrenalectomized rhesus monkey. Am. J. Physiol. 178:361-366, 1954.
  • 10. Hofmann, F.G., E. Knobil and W.L. Caton. The effect of pregnancy on the excretion of water loads by rats. Endocrinology 55:114-115, 1954.
  • 11. Knobil, E., M.G. Hagney, E.J. Wilder and F.N. Briggs. Simplified method for determination of total adrenal cholesterol. Proc. Soc. Exp. Biol. Med. 87:48-50, 1954.
  • 12. Knobil, E., A. Morse, F.G. Hofmann and R.O. Greep. A histologic and histochemical study of hypophyseal-adrenal cortical relationships in the rhesus monkey. Acta. Endocrinol. 17:229-238, 1954.
  • 13. Knobil, E. and F.N. Briggs. Fetal-maternal endocrine interrelations: The hypophyseal-adrenal system. Endocrinology 57:147-152, 1955.
  • 14. Knobil, E. and M.J. Fregly. Effect of ascorbic acid on the adrenal gland after hypophysectomy and after exposure to cold. Endocrinology 56:614-616, 1955.
  • 15. Knobil, E. Discussant: Growth hormone and energy source. In: The hypophyseal growth hormone, nature and actions. R. W. Smith, Jr., O.H. Graebler and C.N.H. Long (eds). Mc-Graw Hill, New York, 1955.
  • 16. Knobil, E. and R.O. Greep Serum electrolytes and carbohydrate metabolism in the hypophysectomized rhesus monkey. Am. J. Physiol. 183:635, 1955.
  • 17. Knobil, E., R.C. Wolf, R.O. Greep and A.E. Wilhelmi. Effect of a primate pituitary growth hormone preparation on nitrogen metabolism in the hypophysectomized rhesus monkey. Endocrinology 60:166-168, 1957.
  • 18. Goldberg, R.C. and E. Knobil. Structure and function of intraocular hypophyseal grafts in the hypophysectomized male rat. Endocrinology 61:742-752, 1957.
  • 19. Knobil, E., A. Morse, R.C. Wolf and R.O. Greep. The action of bovine, porcine and simian growth hormone preparations on the costochondral junction in the hypophysectomized rhesus monkey. Endocrinology 62:348-354, 1958.
  • 20. Knobil, E. and R.O. Greep. Serum electrolytes in the hypophysectomized rhesus monkey. Endocrinology 62:61-63, 1958.
  • 21. Knobil, E., J.L. Kostyo, R.C. Wolf and R.O. Greep. Lack of competitive inhibition between beef and monkey growth hormones in rhesus monkeys. Science 127:1394, 1958.
  • 22. Knobil, E. and J.B. Josimovich. Placental transfer of thyrotropic hormone, throxine, triiodothyronine, and insulin in the rat. Ann. N.Y. Acad. Sci. 75:895-904, 1959.
  • 23. Knobil, E. and R.O. Greep. The physiology of growth hormone with particular reference to its action in the rhesus monkey and the species specificity problem. Recent Prog. Horm. Res. 15:1-69, 1959.
  • 24. Goodman, H.M. and E. Knobil. Mobilization of fatty acids by epinephrine in normal and hypophysectomized rhesus monkeys. Proc. Soc. Exp. Biol. Med. 100:195-197, 1959.
  • 25. Kostyo, J.L. and E. Knobil. The effect of growth hormone on the in vitro incorporation of leucine-2-C14 into the protein of rat diaphragm. Endocrinology 65:395-401, 1959.
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  • 26. Goodman, H.M. and E. Knobil. The effects of fasting and of growth hormone administration on plasma fatty acid concentration in normal and hypophysectomized rhesus monkeys. Endocrinology 65:451-458, 1959.
  • 27. Knobil, E., J.L. Kostyo and R.O. Greep. Production of ovulation in the hypophysectomized rhesus monkey. Endocrinology 65:487-493, 1959.
  • 28. Kostyo, J.L. and E. Knobil. The stimulation of leucine-2-C14 incorporation into the protein of isolated rat diaphragm by simian growth hormone added in vitro. Endocrinology 65:525-528, 1959.
  • 29. Goodman, H.M. and E. Knobil. Effect of pH and route of administration on the fatty acid mobilizing activity of growth hormone solutions. Endocrinology 65:977-979, 1959.
  • 30. Kostyo, J.L., J. Hotchkiss and E. Knobil. Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro. Science 130:1653-1654, 1959.
  • 31. Knobil, E. Direct evidence for fatty acid mobilization in response to growth hormone administration in rat. Proc. Soc. Exp. Biol. Med. 101:288-289, 1959.
  • 32. Goodman, H.M. and E. Knobil. Effect of adrenergic blocking agents on fatty acid mobilization during fasting. Proc. Soc. Exp. Biol. Med. 102:493-495, 1959.
  • 33. Knobil, E. and R.O. Greep. The detection of growth hormone in plasma. In: Hormones in Human Plasma. H. N. Antoniades (ed.), Little Brown and Co., 1960, pp.141-148.
  • 34. Knobil, E., G.R. Best and H.M. Goodman. The hypoglycemic action of simian and bovine growth hormone in hypophysectomized rhesus monkeys Endocrinology 68:723-725, 1961.
  • 35. Franklin, M.J. and E. Knobil. The influence of hypophysectomy and of growth hormone administration on the oxidation of palmitate-1-C14 by the unanesthetized rat. Endocrinology 68:867-872, 1961.
  • 36. Josimovich, J.B. and E. Knobil. Placental transfer of I131-insulin in the rhesus monkey. Am. J. Physiol. 200:471-476, 1961.
  • 37. Brande, P.F. and E. Knobil. Further evidence for amino acid transport as a site of action of growth hormone. Proc. Soc. Exp. Biol. Med. 110:5-6, 1962.
  • 38. Knobil, E. and J.B. Josimovich. The interstitial cell stimulating activity of ovine, equine and human luteinizing hormone preparations in the hypophysectomized male rhesus monkey. Endocrinology 69:139-151, 1961.
  • 39. Goodman, H.M. and E. Knobil. Growth hormone and fatty acid mobilization: The role of the pituitary, adrenal and thyroid. Endocrinology 69:187-189, 1961.
  • 40. Goodman, H.M. and E. Knobil. Some endocrine factors in regulation of fatty acid mobilization during fasting. Am. J. Physiol. 201:1-3, 1961.
  • 41. Knobil, E. The pituitary growth hormone: Some physiological considerations. In: Growth in Living Systems, Zarrow, M.X. (ed.), Basic Books, Inc., New York, 1961, pp. 354-381.
  • 42. Peckham, W.D. and E. Knobil. Amino acid concentration by the rat diaphragm in response to injury and to some metabolic inhibitors. Biochim. Biophys. Acta 63:207, 1962, pp. 207-209.
  • 43. Knobil, E. and R. Sandler. The physiology of the adenohypophyseal hormones. In: Comparative Endocrinology, von Euler, U.S. and H. Heller (eds.), Academic Press, New York, Vol. 1, 1963, pp. 447-491.
  • 44. Ball, E.G. and E. Knobil. Insulinlike activity of serum from normal and hypophysectomized monkeys. Endocrinology 72:658-661, 1963.
  • 45. Fritz, G.R. and E. Knobil. The effect of insulin on extracellular space and tissuewater content of the isolated rat diaphragm. Biochim. Biophys. Acta 78:773-774, 1963.
  • 46. Fritz, G.R. and E. Knobil. In vitro stimulation by insulin of a-amino-isobutyric acid transport in the absence of protein synthesis. Nature 200:682, 1963.
  • 47. Knobil, E. and J. Hotchkiss. Growth hormone. In: Annual Review of Physiology, Vol. 26, 1964, pp. 47-74.
  • 48. Goodman, H.M. and E. Knobil. Hypophysectomy and the lipolytic action of epinephrine in vitro. Proc. Soc. Exp. Biol. Med. 115:849-852, 1964.
  • 49. Fritz, G.R. and E. Knobil. Amino acid transport and protein synthesis in muscle. Action of insulin. Proc. Soc. Exp. Biol. Med. 116:873-875, 1964.
  • 50. Josimovich, J.B., S. Ingbar and E. Knobil. Transplacental passage of I131 thyroxin in the rhesus monkey. Transcript of the Third Rochester Trophoblast Conference, Lund, C.J. and H.A. Thiede (eds.), Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 1965, pp. 178-195.

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  • 51. Knobil, E. Placental amino acid transport in the rhesus monkey. Transcript of the Third Rochester Trophoblast Conference, Lund, C.J. and H.A. Thiede (eds.), Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 1965, pp. 235-251.
  • 52. Knobil, E. Tenth Bowditch Lecture. The pituitary growth hormone: An adventure in physiology. The Physiologist 9:25-44, 1966.
  • 53. Meyer, V. and E. Knobil. Stimulation of growth hormone secretion by vasopressin in the rhesus monkey. Endocrinology 79:1016-1018, 1966.
  • 54. Knobil, E. Summary, In: Initiation of Labor, Proc. Interdisciplinary Conference on the Initiation of Labor, USPHS publication no. 1390, 1966, pp. 217-225.
  • 55. Meyer, V. and E. Knobil. Growth hormone secretion in the unanesthetized rhesus monkey in response to noxious stimuli. Endocrinology 80:163-171, 1967.
  • 56. Neill, J.D., W.D. Peckham and E. Knobil. Apparent absence of immunological cross-reactivity between human and simian gonadotropic hormones as determined by radioimmunoassay. Nature 213:1014-1015, 1967.
  • 57. Neill, J.D., E.D.B. Johansson, J.K. Datta and E. Knobil. Relationship between the plasma levels of luteinizing hormone and progesterone during the normal menstrual cycle. J. Clin. Endocrinol. Metab. 27:1167-1173, 1967.
  • 58. Neill, J.D., E.D.B. Johansson and E. Knobil. Levels of progesterone in peripheral plasma during the menstrual cycle of the rhesus monkey. Endocrinology 81:1161-1164, 1967.
  • 59. Knobil, E. and V. Meyer. Observations on the secretion of growth hormone, and its blockade, in the rhesus monkey. Ann. N.Y. Acad. Sci. 148:459-470, 1968.
  • 60. Johansson, E.D.B., J.D. Neill and E. Knobil. Periovulatory progesterone concentration in the peripheral plasma of the rhesus monkey with a methodologic note on the detection of ovulation. Endocrinology 82:143-148, 1968.
  • 61. Peckham, W.D., J. Hotchkiss, E. Knobil and C.S. Nicoll. Prolactin activity of homogeneous primate growth hormone preparations. Endocrinology 82:1247-1248, 1968.
  • 62. Knobil, E., J.D. Neill and E.D.B. Johansson. Influence of hypophysectomy, sham hypophysectomy and other surgical procedures on luteal function in the rhesus monkey. Endocrinology 82:410-415, 1968.
  • 63.Knobil, E., V. Meyer and A.V. Schally. Hypothalamic extracts and the secretion of growth hormone in the rhesus monkey. In: Growth Hormone, A. Pecile and E.E. Muller (eds.), Excerpta Medical International Congress Series 158, 1968, pp. 226-237.
  • 64. Neill, J.D., E.D.B. Johansson and E. Knobil. Patterns of circulating progesterone concentrations during the fertile menstrual cycle and the remainder of gestation in the rhesus monkey. Endocrinology 84:45-48, 1969.
  • 65. Neill, J.D., E.D.B. Johansson and E. Knobil. Failure of hysterectomy to influence the normal pattern of cyclic progesterone secretion in the rhesus monkey. Endocrinology 84:464-465, 1969.
  • 66. Meyer, V. and E. Knobil. Etude, chez le singe rhesus, de la decroissance plasmatique de l’hormone somato trope de singe et de l’hormone somatotrope humaine marquees ou non a l’iode 131. Annales d’Endocrinologie 30:345-356, 1969.
  • 67. Knobil, E., J. Hotchkiss and V. Meyer. Specificity in the actions of growth hormone. C.N.R.S. Symposium on “The Zoological Specificity of Pituitary Hormones and their Activities”, Paris, 1968. Colloques internationaux du C.N.R.S. No. 177, 1969, pp. 181-190.
  • 68. Freigang, B. and E. Knobil. Patent ductus arteriosus with pulmonary hypertension and arteritis in a rhesus monkey. Yale J. Biol. Med. 40:239-242, 1967.
  • 69. Schimmel, R.J. and E. Knobil. Role of free fatty acids in stimulation of gluconeogenesis during fasting. Am. J. Physiol. 217:1803-1808, 1969.
  • 70. Csapo, A.I., E. Knobil, M. Pulkkinen, H.J. Van Der Molen, I.F. Sommerville, and W.G. Wiest. Progesterone withdrawal during hypertonic saline-induced abortions. Am. J. Obst. Gyn. 105:1132-1133, 1969.
  • 71. Sakuma, M. and E. Knobil. Inhibition of endogenous growth hormone secretion by exogeneous growth hormone infusion in the rhesus monkey. Endocrinology 86:890-894, 1970.
  • 72. Sakuma, M. and E. Knobil. Failure of high rates of glucocorticoid infusion to inhibit growth hormone secretion in the rhesus monkey. Endocrinology 86:895-897, 1970.
  • 73. Monroe, S.E., W.D. Peckham, J.D. Neill and E. Knobil. A radioimmunoassay for rhesus monkey luteinizing hormone (RhLH). Endocrinology 86:1012-1018, 1970.
  • 74. Monroe, S.E., L.E. Atkinson and E. Knobil. Patterns of circulating luteinizing hormone and their relation to plasma progesterone levels during the menstrual cycle of the rhesus monkey. Endocrinology 87:453-455, 1970.
  • 75. Niswender, G.D., S.E. Monroe, W.D. Peckham, A.R. Midgley, Jr., E. Knobil, and L.E. Reichert, Jr. Radioimmunoassay for rhesus monkey luteinizing hormone (LH) with anti-ovine LH serum and ovine LH131I. Endocrinology 88:1327-1331, 1971.
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  • 76. Atkinson, L.E., A.N. Bhattacharya, S.E. Monroe, D.J. Dierschke and E. Knobil. Effects of gonadectomy on plasma LH concentration in the rhesus monkey. Endocrinology 87:847-849, 1970.
  • 77. Dierschke, D.J., A.N. Bhattacharya, L.E. Atkinson and E. Knobil. Circhoral oscillations of plasma LH levels in the ovariectomized rhesus monkey. Endocrinology 87:850-853, 1970.
  • 78. Schimmel, R.J. and E. Knobil. Insulin, free fatty acids, and stimulation of hepatic gluconeogenesis during fasting. Am. J. Physiol. 218:1540-1547, 1970.
  • 79. Channing, C.P., M. Taylor, E. Knobil, C.S. Nicoll and C.W. Nichols, Jr. Secretion of prolactin and growth hormone by cultures of adult simian pituitaries. Proc. Soc. Exp. Biol. Med. 135:540-542, 1970.
  • 80. Hotchkiss, J., L.E. Atkinson and E. Knobil. Time course of serum estrogen and luteinizing hormone (LH) concentrations during the menstrual cycle of the rhesus monkey. Endocrinology 89:177-183, 1971.
  • 81. Yamaji, T., D.J. Dierschke, J. Hotchkiss, A.N. Bhattacharya, A.H. Surve and E. Knobil. Estrogen induction of LH release in the rhesus monkey. Endocrinology 89:1034-1041, 1971.
  • 82. Csapo, A.I., E. Knobil, H.J. Van Der Molen, and W.G. Wiest. Peripheral plasma progesterone levels during human pregnancy and labor. Am. J. Obstet. Gynec. 110:630-632, 1971.
  • 83. Neill, J.D. and E. Knobil. On the nature of the initial luteotropic stimulus of pregnancy in the rhesus monkey. Endocrinology 90:34-38, 1972.
  • 84. Knobil, E., D.J. Dierschke, T. Yamaji, F.J. Karsch, J. Hotchkiss and R.F. Weick. Role of estrogen in the positive and negative feedback control of LH secretion during the menstrual cycle of the rhesus monkey. In: Gonadotropins, Saxena, B.B. (ed.), John Wiley & Sons, Inc., 1972, pp. 72-86.
  • 85. Yamaji, T., D.J. Dierschke, A.N. Bhattacharya and E. Knobil. The negative feedback control by estradiol and progesterone of LH secretion in the ovariectomized rhesus monkey. Endocrinology 90:771-777, 1972.
  • 86. Bhattacharya, A.N., D.J. Dierschke, T. Yamaji and E. Knobil. The pharmacologic blockade of the circhoral mode of LH secretion in the ovariectomized rhesus monkey. Endocrinology 90:778-786, 1972.
  • 87. Knobil, E. Hormonal control of the menstrual cycle and ovulation in the rhesus monkey. Acta Endocrinologica, Supplement 166:137-144, 1972.
  • 88. Weick, R.F., D.J. Dierschke, F.J. Karsch, T. Yamaji and E. Knobil. The refractory period following estrogen-induced LH surges in the rhesus monkey. Endocrinology 91:1528-1530, 1972.
  • 89. Karsch, F.J., D.J. Dierschke, R.F. Weick, T. Yamaji, J. Hotchkiss and E. Knobil. Positive and negative feedback control by estrogen of luteinizing hormone secretion in the rhesus monkey. Endocrinology 92:799-804, 1973.
  • 90. Karsch, F.J., L.C. Krey, R.F. Weick, D.J. Dierschke and E. Knobil. Functional luteolysis in the rhesus monkey: The role of estrogen. Endocrinology 92:1148-1152, 1973.
  • 91. Dierschke, D.J., T. Yamaji, F.J. Karsch, R.F. Weick, G. Weiss and E. Knobil. Blockade by progesterone of estrogen-induced LH and FSH release in the rhesus monkey. Endocrinology 92:1496-1501, 1973.
  • 92. Yamaji, T., W.D. Peckham, L.E. Atkinson, D.J. Dierschke and E. Knobil Radioimmunoassay of rhesus monkey follicle-stimulating hormone (RhFSH). Endocrinology 92:1652-1659, 1973.
  • 93. Peckham, W.D., T. Yamaji, D.J. Dierschke and E. Knobil. Gonadal function and the biological and physicochemical properties of follicle-stimulating hormone. Endocrinology 92:1660-1666, 1973.
  • 94. Reinius, S., G.R. Fritz and E. Knobil Ultrastructure and endocrinological correlates of an early implantation site in the rhesus monkey. J. Reprod. Fert. 32:171-173, 1973.
  • 95. Krey, L.C., W.R. Butler, G. Weiss, R.F. Weick, D.J. Dierschke and E. Knobil. Influences of endogenous and exogenous gonadal steroids on the actions of synthetic LRF in the rhesus monkey. In: Hypothalamic Hypophysiotropic Hormones, C. Gual and E. Rosemberg (eds.), Excerpta Medical International Congress Series 263, 1973, pp. 39-47.
  • 95. Knobil, E. On the regulation of the primate corpus luteum. Biol. Reprod. 8:246-258, 1973.
  • 96. Weiss, G., R.F. Weick, E. Knobil, S.R. Wolman and F. Gorstein. An X-O anomaly and ovarian dysgenesis in a rhesus monkey. Folia Primatologica 19:24-27, 1973.
  • 97. Karsch, F.J., D.J. Dierschke and E. Knobil. Sexual differentiation of pituitary function: Apparent difference between primates and rodents. Science 179:484-486, 1973.
  • 98. Karsch, F.J., R.F. Weick, W.R. Butler, D.J. Dierschke, L.C. Krey, G. Weiss, J. Hotchkiss, T. Yamaji and E. Knobil. Induced LH surges in the rhesus monkey: Strength-duration characteristics of the estrogen stimulus. Endocrinology 92:1740-1747, 1973.
  • 99. Karsch, F.J., R.F. Weick, J. Hotchkiss, D.J. Dierschke and E. Knobil. An analysis of the negative feedback control of gonadotropin secretion utilizing chronic implantation of ovarian steroids in ovariectomized rhesus monkeys. Endocrinology 93:478-486, 1973.
  • 100. Weiss, G., D.J. Dierschke, F.J. Karsch, J. Hotchkiss, W.R. Butler and E. Knobil. The influence of lactation on luteal function in the rhesus monkey. Endocrinology 93:954-959, 1973.
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  • 101. Weick, R.F., D.J. Dierschke, F.J. Karsch, W.R. Butler, J. Hotchkiss and E. Knobil. Periovulatory time courses of circulating gonadotropic and ovarian hormones in the rhesus monkey. Endocrinology 93:1140-1147, 1973.
  • 102. Dierschke, D.J., F.J. Karsch, R.F. Weick, G. Weiss, J. Hotchkiss and E. Knobil. Hypothalamic-pituitary regulation of puberty: Feedback control of gonadotropin secretion in the rhesus monkey. In: Control of Onset of Puberty. M.M. Grumbach, G.D. Grave and F.E. Mayer (eds.), John Wiley & Sons, Inc., 1974, pp. 104-114.
  • 103. Knobil, E. On the control of gonadotropin secretion in the rhesus monkey. Rec. Prog. Hormone Res. 30:1-46, 1974.
  • 104. Dierschke, D.J., G. Weiss and E. Knobil. Sexual maturation in the female rhesus monkey and the development of estrogen-induced gonadotropic hormone release. Endocrinology 94:198-206, 1974.
  • 105. Weiss, G., J. Hotchkiss, D.J. Dierschke and E. Knobil. Metabolic clearance rate of progesterone during lactation in the rhesus monkey. Endocrinology 94:198-206, 1974.
  • 106. Wintour, E.M., E. Knobil, B.A. Scoggins, S.L. Skinner and J.P. Coghlan. The reninaldosterone systems in the pregnant rhesus monkey (Macaca mulatta). Clin. Exp. Pharm. Phys. 1:167-170, 1974.
  • 107. Knobil, E. Maturation of the neuroendocrine control of gonadotropin secretion in the rhesus monkey. In: Sexual Endocrinology of the Perinatal Period. M. G. Forest and J. Bertrand (eds.), INSERM, Paris, 1974, pp. 205-218.
  • 108. Karsch, F.J., R.F. Weick, W.R. Butler, D.J. Dierschke, L.C. Krey, G. Weiss, J. Hotchkiss, T. Yamaji and E. Knobil. Analysis of the strength-duration characteristics of the estrogen stimulus for the LH surge in the rhesus monkey. Schering Workshop on Central Actions of Estrogenic Hormones, Berlin, 1974, pp. 181-186.
  • 109. Goodman, R.L., J. Hotchkiss, F.J. Karsch and E. Knobil. Diurnal variations in serum testosterone concentrations in the adult male rhesus monkey. Biol. Reprod. 11:624-630, 1974.
  • 110. Krey, L.C., W.R. Butler and E. Knobil. Surgical disconnection of the medial basal hypothalamus and pituitary function in the rhesus monkey. I. Gonadotropin secretion. Endocrinology 96:1073-1087, 1975.
  • 111. Krey, L.C., K.-H. Lu, W.R. Butler, J. Hotchkiss, F. Piva and E. Knobil. Surgical disconnection of the medial basal hypothalamus and pituitary function in the rhesus monkey. II. Growth hormone and cortisol secretion. Endocrinology 96:1088-1093, 1975.
  • 112. Butler, W.R., L.C. Krey, J. Espinosa-Campos and E. Knobil. Surgical disconnection of the medial basal hypothalamus and pituitary function in the rhesus monkey. III. Thyroxine secretion. Endocrinology 96:1094-1098, 1975.
  • 113.Butler, W.R., L.C. Krey, K.-H. Lu, W.D. Peckham and E. Knobil. Surgical disconnection of the medial basal hypothalamus and pituitary function in the rhesus monkey. IV. Prolactin secretion. Endocrinology 96:1099-1105, 1975.
  • 114. Butler, W.R., J. Hotchkiss and E. Knobil. Functional luteolysis in the rhesus monkey: Ovarian estrogen and progesterone during the luteal phase of the menstrual cycle. Endocrinology 96:1509-1512, 1975.
  • 115.Atkinson, L.E., J. Hotchkiss, G.R. Fritz, A.H. Surve, J.D. Neill and E. Knobil. Circulating levels of steroids and chorionic gonadotropin during pregnancy in the rhesus monkey, with special attention to the rescue of the corpus luteum in early pregnancy. Biol. Reprod. 12:335-345, 1975.
  • 116. Krey, L.C., W.R. Butler and E. Knobil. The role of medial basal hypothalamus in the control of pituitary function in the rhesus monkey. In: Hypothalamic Hormones. M. Motta, P.G. Crosignani and L. Martini (eds.), Academic Press, 1975, 255-259.
  • 117. Knobil, E. and L.C. Krey. Neuroendocrine control of gonadotropin secretion in the rhesus monkey. In: Neuroendocrine Regulation of Fertility. Kumar, T.C. Anand (ed.), S. Karger, 1976, pp. 278-285.
  • 118. Weiss, G., W.R. Butler, J. Hotchkiss, D.J. Dierschke and E. Knobil. Periparturitional serum concentrations of prolactin, the gonadotropins and the gonadal hormones in the rhesus monkey. Proc. Soc. Exp. Biol. Med. 151:113-116, 1976.
  • 119. Peckham, W.D. and E. Knobil. The effects of ovariectomy, estrogen replacement, and neuraminidase treatment on the properties of the adenohypophysial glycoprotein hormones of the rhesus monkey. Endocrinology 98:1054-1060, 1976.
  • 120. Peckham, W.D. and E. Knobil. Qualitative changes in the pituitary gonadotropins of the male rhesus monkey following castration. Endocrinology 98:1061-1064, 1976.
  • 121. Weiss, G., W.R. Butler, D.J. Dierschke and E. Knobil. Influence of suckling on gonadotropin secretion in the postpartum rhesus monkey. Proc. Soc. Exp. Biol. Med. 153:330-331, 1976.
  • 122. McCormack, J.T., T.M. Plant, D.L. Hess and E. Knobil. The effect of luteinizing hormone releasing hormone (LHRH) antiserum administration on gonadotropin secretion in the rhesus monkey. Endocrinology 100:663-667, 1977.
  • 123. Knobil, E., R.R. Sonnenschein, and I.S. Edelman. (eds.) Annual Review of Physiology 39, 1977.
  • 124. Knobil, E., T.M. Plant, D.L. Hess and Y. Nakai. On the neuroendocrine control of ovarian function in the rhesus monkey. In: Endocrinology of the Ovary, Scholler, R. (ed.), editions SEPE, 1978, pp. 155-161.
  • 125. Peckham, W.D., D.L. Foster and E. Knobil. A new substance resembling LH in the blood of rhesus monkeys. Endocrinology 100:826-834, 1977.
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  • 126. Hess, D.L., R.H. Wilkins, J.Moossy, J.L. Chang, T.M.Plant, J.T. McCormack, Y. Nakai and E. Knobil. Estrogen-induced gonadotropin surges in decerebrated female rhesus monkeys with medial basal hypothalamic peninsulae. Endocrinology 101:1264-1271, 1977.
  • 127. Knobil, E. The Endocrine Society, Presidential Address. Endocrinology 101:1647-1651, 1977.
  • 128. Knobil, E. and T.M. Plant. The neuroendocrine control of gonadotropin secretion in the female rhesus monkey. In: Frontiers in Neuroendocrinology, Ganong, W.E. and L. Martini (eds.), Raven Press, Vol. 5, 1978, pp. 249-264.
  • 129. Plant, T.M., L.C. Krey, J. Moossy, J.T. McCormack, D.L. Hess and E. Knobil. The arcuate nucleus and the control of gonadotropin and prolactin secretion in the female rhesus monkey (Macaca mulatta). Endocrinology 102:52-62, 1978.
  • 130. Knobil, E. and T.M. Plant. The hypothalamic regulation of LH and FSH secretion in the rhesus monkey. In: The Hypothalamus, S. Reichlin, R.J. Baldessarini and J.B. Martin (eds.), Raven Press, 1978, pp. 359-372.
  • 131. Knobil, E., T.M. Plant, D.L. Hess and Y. Nakai. The neuroendocrine control of the ovarian cycle in the rhesus monkey. In: Reproduction and Evolution, Australian Academy of Science, 1977, 221-223.
  • 132. Nakai, Y., T.M. Plant, D.L. Hess, E.J. Keogh and E. Knobil. On the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion in the rhesus monkey. Endocrinology 102:1008-1014, 1978.
  • 133. Plant, T.M., Y. Nakai, P. Belchetz, E.J. Keogh and E. Knobil. The sites of action of estradiol and phentolamine in the inhibition of the pulsatile, circhoral discharges of LH in the rhesus monkey (Macaca mulatta). Endocrinology 102:1015-1018, 1978.
  • 134. Plant, T.M., D.L. Hess, J. Hotchkiss and E. Knobil. Testosterone and the control of gonadotropin secretion in the male rhesus monkey (Macaca mulatta). Endocrinology 103:535-541, 1978.
  • 135. Belchetz, P., B. Dufy and E. Knobil. Identification of inhibitory and stimulatory control of prolactin secretion in the rhesus monkey. Neuroendocrinology 27:32-38, 1978.
  • 136. Belchetz, P., T.M. Plant, Y. Nakai, E.J. Keogh and E. Knobil. Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin releasing hormone. Science 202:631-633, 1978.
  • 137. Knobil, E. The neural control of the menstrual cycle. In: Recent Advances in Reproduction and Regulation of Fertility. G. P. Talwar (ed.), Elsevier/North Holland Biomedical Press, 1979, pp. 3-8.
  • 138. Knobil, E. Organismic Physiology: The New Frontier. In: Claude Bernard and the Internal Environment: A Memorial Symposium. E.D. Robin, (ed.), Marcel Dekker, Inc. 1979, 229-239.
  • 139. Plant, T.M., J. Moossy, D.L. Hess, Y. Nakai, J.T. McCormack and E. Knobil. Further studies on the effects of lesions in the rostral hypothalamus on gonadotropin secretion in the female rhesus monkey (Macaca mulatta). Endocrinology 105:465-473, 1979.
  • 140. Dufy, B., L. Dufy-Barbe, J.D. Vincent and E. Knobil. Etude electrophysiologique des neurones hypothalamiques et regulation gonadotrope chez le singe rhesus. Journal de Physiologie, Paris 75:105-108, 1979.
  • 141. Knobil, E. The neuroendocrine control of the menstrual cycle. Rec. Prog. Hormone Res. 36:53-88, 1980.
  • 142. Knobil, E., T.M. Plant, L. Wildt, P.E. Belchetz and G.R. Marshall. Control of the rhesus monkey menstrual cycle: Permissive role of the hypothalamic gonadotropin-releasing hormone. Science 207:1371-1373, 1980.
  • 143. Wildt, L., G. Marshall and E. Knobil. Experimental induction of puberty in the infantile female rhesus monkey. Science 207:1373-1375, 1980.
  • 144. Attardi, B., J. Hotchkiss and E. Knobil. Monkey pituitary oestrogen receptors and the biphasic action of oestradiol on gonadotropin secretion. Nature 285:252-254, 1980.
  • 145. Inskeep, E.K., L. Wilson, Jr., W.R. Butler, D.J. Dierschke, G.R. Fritz and E. Knobil. Endometrial secretion of prostaglandins during the ovarian cycle and early pregnancy. In: The Endometrium, Kimball, F.A. (ed.), Spectrum Publications, Inc. 1980, pp. 287-309.
  • 146. Knobil, E. The role of signal pattern in the hypothalamic control of gonadotropin secretion. In: Rhythmes et Reproduction, R. Ortavant and A. Reinberg (eds.), Masson, 1980, pp. 73-79.
  • 147. Knobil, E. The impact of reproductive biology on academic obstetrics: The viewpoint of an endocrinologist. In: The Current Status and Future of Academic Obstetrics. J. Z. Bowers and E.F. Purcell (eds.), Independent Publishing Group, 1980, pp. 109-115.
  • 148. Plant, T.M., E. Schallenberger, D.L. Hess, J.T. McCormack, L. Dufy-Barbe and E.Knobil. Influence of suckling on gonadotropin secretion in the female rhesus monkey (Macaca mulatta). Biol. Reprod. 23:760-766, 1980.
  • 149. Goodman, R.L. and E. Knobil. The sites of action of ovarian steroids in the regulation of LH secretion. Neuroendocrinology 32:57-63, 1981.
  • 150. Knobil, E. Patterns of hypophysiotropic signals and gonadotropin secretion in the rhesus monkey. Biol. Reprod. 24:44-49, 1981.
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  • 151. Knobil, E. William Harvey and the physiology of reproduction. The Physiologist 24:3-7, 1981.
  • 152. Krey, L.C., D.L. Hess, W.R. Butler, J. Espinosa-Campos, K.-H. Lu, F. Piva, T.M. Plant and E. Knobil. Medial basal hypothalamic disconnection and the onset of puberty in the female rhesus monkey. Endocrinology 108:1944-1948, 1981.
  • 153. Wildt, L., A. Hausler, J.S. Hutchison, G. Marshall and E. Knobil. Estradiol as a gonadotropin releasing hormone in the rhesus monkey. Endocrinology 108:2011-2013, 1981.
  • 154. Schallenberger, E., D.W. Richardson and E. Knobil. The role of prolactin in the lactational amenorrhea of the rhesus monkey (Macaca mulatta). Biol. Reprod. 25:370-374, 1981.
  • 155. Wildt, L., A. Hausler, G. Marshall, J.S. Hutchison, T.M. Plant, P.E. Belchetz and E. Knobil. Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion on the rhesus monkey. Endocrinology 109:376-385, 1981.
  • 156. Wildt, L., J.S. Hutchison, G. Marshall, C.R. Pohl and E. Knobil. On the site of action of progesterone in the blockade of the estradiol-induced gonadotropin discharge in the rhesus monkey. Endocrinology 109:1293-1294, 1981.
  • 157. Resko, J.A., W.E. Ellinwood and E. Knobil. Differential effects of progesterone on secretion of gonadotropic hormones in the rhesus monkey. Am. J. Physiology: Endo. and Metab. 240:489-492, 1981.
  • 158. Knobil, E. Discussion to “The Neuroendocrine Control of the Menstrual Cycle”. Rec. Prog. Hormone Res. 37:703-707, 1981.
  • 159. Knobil, E. Editorial: Patterns of hormonal signals and hormone action. N. Engl. J. Med. 305:1582-1583, 1981.
  • 160. Knobil, E. Patterns of GnRH signalling and gonadotropin secretion in the rhesus monkey. In: The Gonadotropins: Basic Science and Clinial Aspects in Females. C. Flamignia and J.R. Givens (eds.), Academic Press, 1982, pp. 117-122.
  • 161. Hotchkiss, J., D.J. Dierschke, W.R. Butler, G.R. Fritz and E. Knobil. Relation between levels of circulating ovarian steroids and pituitary gonadotropin content during the menstrual cycle of the rhesus monkey. Biol. Reprod. 26:241-248, 1982.
  • 162. Pohl, C.R. and E. Knobil. The role of the central nervous system in the control of ovarian function in higher primates. Ann. Rev. Physiol. 44:583-593, 1982.
  • 163. Pohl, C.R., D.W. Richardson, G. Marshall, and E. Knobil. Mode of action of progesterone in the blockade of gonadotropin surges in the rhesus monkey. Endocrinology 110:1454-1455, 1982.
  • 164. Wilson, R.C. and E. Knobil. Acute effects of N-methyl-DL-aspartate on the release of pituitary gonadotropins and prolactin in the adult female rhesus monkey. Brain Research 248:177-179, 1982.
  • 165. Pohl, C.R., D.W. Richardson, J.S. Hutchison, J.A. Germak and E. Knobil. Hypophysiotropic signal frequency and the functioning of the pituitary-ovarian system in the rhesus monkey. Endocrinology 112:2076-2080, 1983.
  • 166. Knobil, E. LHRH and the control of gonadotropin secretion in the female rhesus monkey. In: Role of Peptides and Proteins in Control of Reproduction. S. M.McCann and Dharam S. Dhindsa, (eds.), Elsevier Biomedical, 1983, pp. 27-31.
  • 167. Knobil, E. and L. Wildt. Neuroendocrine control of ovarian function in higher primates. In: Brain and Pituitary Peptide II, S. Karger AG, 1983, pp. 11-27.
  • 168. Knobil, E. Control of ovulation in the rhesus macaque. In: Neuroendocrine Aspects of Reproduction, Reid L. Norman, (ed.), Academic Press, 1983, pp. 257-262.
  • 169. Wilson, R.C., J.S. Kesner, J.-M. Kaufman, T. Uemura, T. Akema and E. Knobil. Central electrophysiologic correlates of pulsatile luteinizing hormone secretion in the rhesus monkey. Neuroendocrinology, 39:256-260, 1984.
  • 170. Richardson, D.W., L. T. Goldsmith, C.R. Pohl, E. Schallenberger and E. Knobil. The role of prolactin in the regulation of the primate corpus luteum. Journal of Clin. Endocrinology and Metabolism. 60:501-504, 1985.
  • 171. Kaufman, J.-M., J.S. Kesner, R.C. Wilson and E. Knobil. Electrophysiologic manifestation of “LHRH Pulse Generator” activity in the rhesus monkey: Influence of beta-Adrenergic and Dopaminergic blocking agents. Endocrinology. 116:1327-1333, 1985.
  • 172. Knobil, E. and J. Hotchkiss. The circhoral gonadotropin releasing hormone (GnRH) pulse generator of the hypothalamus and its physiological significance In: Ultradian Rhythms in Physiology and Behavior. H. Schultz and P. Lavie (eds.), Experimental Brain Research, Supplement 12, Springer-Verlag, 1985, pp. 32-40
  • 173. Knobil, E. La secretion pulsatile gonadotrope et sa signification physiologique. In: Actualites Gynecologiques, A. Netter and A. Gorins (eds.), Masson, Paris, 1985, pp. 149-153.
  • 174. Kesner, J.S., J.-M. Kaufman, R.C. Wilson and E. Knobil. On the short-loop feedback regulation of the hypothalamic luteinizing hormone releasing hormone “pulse generator” in the rhesus monkey. Neuroendocrinology 42:109-111, 1986.
  • 175. Knobil, E. Neuroendocrine control of the menstrual cycle. In: Reproductive Medicine. E. Steinberger, and A. Steinberger (eds.), Raven Press, 1986, pp. 139-14.
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  • 176. Kesner, J.S., J.-M. Kaufman, R.C. Wilson, G. Kuroda and E. Knobil. The effect of morphine on the electrophysiological activity of the hypothalamic luteinizing hormone releasing hormone pulse generator in the rhesus monkey. Neuroendocrinology 43:686-688, 1986.
  • 177. Silverman, A. J., R. Wilson, J.S. Kesner and E. Knobil. Hypothalamic localization of multiunit electrical activity associated with pulsatile LH release in the rhesus monkey. Neuroendocrinology. 44:168-171, 1986.
  • 178. Knobil, E. A hypothalamic pulse generator that governs mammalian reproduction. News in Physiological Sciences 2:42-43, 1987.
  • 179. Knobil, E. The control of the menstrual cycle. In: Gynecological Endocrinology, A. R. Genazzani, A. Volpe and F. Facchinetti (eds.) Parthenon Press, 1986, pp. 39-42.
  • 180. Knobil, E. and J. Hotchkiss. The menstrual cycle and its neuroendocrine control. In: The Physiology of Reproduction , E. Knobil and J.D. Neill (eds.), Raven Press, 1988, pp. 1971-1994.
  • 181. Knobil, E. The electrophysiology of the hypothalamic gonadotropic hormone releasing hormone (GnRH) pulse generator in the rhesus monkey. In: Endocrinology and Physiology of Reproduction. P.C.K. Leung, D.T. Armstrong, K.B. Ruf, W.H. Moger and H.G. Friesen (eds.) Plenum Press, 1987, pp. 23-26.
  • 182. Kesner, J.S., R.C. Wilson, J.-M. Kaufman, J. Hotchkiss, Y. Chen, H. Yamamoto, R.R. Pardo and E. Knobil. Unexpected responses of the hypothalamic gonadotropin-releasing hormone “pulse generator” to physiological estradiol inputs in the absence of the ovary. Proc. Natl. Acad. of Sciences, 84:8745-8749, 1987.
  • 183. Knobil, E. The hypothalamic gonadotropic hormone releasing hormone (GnRH) pulse generator in the rhesus monkey and its neuroendocrine control. Human Reproduction. 3(1):29-31, 1988.
  • 184. Knobil, E. and J. Hotchkiss. The neuroendocrine control of ovulation. Human Reproduction. 3(4):469-472, 1988.
  • 185. Knobil, E. Elettrofisiologia del generatore pulsatile ipotalamico del Gonadotropin-releasing Hormone (GnRH) nella Scimmia Rhesus. In: Bioritmi Endocrini Fisiologia, Diagnostica ed Applicazioni Terapeutiche. M. Filicori, C. Flamigni, W.F. Crowley, Jr. (eds.) CIC Press International Editions, 1988, pp. 87-90.
  • 186. Knobil, E. The electrophysiology of the GnRH pulse generator in the rhesus monkey. The Journal of Steroid Biochemistry. 33:669-671, 1989.
  • 187. Knobil, E. The circhoral hypothalamic clock that governs the 28 day menstrual cycle. In: Theoretical Models for Cell to Cell Signalling. A. Goldbeter (ed.), Academic Press, 1989, pp. 353-358.
  • 188. Knobil, E. The GnRH Pulse Generator. In: Control of the Onset of Puberty, III. H.A. Delemarre van-de Waal, T. M. Plant, G.P. Van Rees, J. Schoemaker (eds.), Elsevier Science Publishers, Amsterdam, 1989, pp. 11-20.
  • 189. Germak, J.A. and E. Knobil. Control of puberty in the rhesus monkey. In: Control of Onset of Puberty. M. Grumbach and P. C. Sizonenko, (eds.), Academic Press, 1990, pp. 69-81.
  • 190. Williams, C.L., M. Nishihara, J-C. Thalabard, P.M. Grosser, J. Hotchkiss and E. Knobil. Corticotropin releasing factor (CRF) and gonadotropin releasing hormone (GnRH) pulse generator activity in the rhesus monkey: Electrophysiological studies. Neuroendocrinology 52:133-137, 1990.
  • 191. Williams, C.L., M. Nishihara, J-C. Thalabard, K.T. O’Byrne, P.M. Grosser, J. Hotchkiss and E.Knobil. Duration and frequency of multiunit electrical activity associated with the hypothalamic gonadotropin releasing hormone (GnRH) pulse generator in the rhesus monkey: differential effects of morphine. Neuroendocrinology 52:225-228, 1990.
  • 192. Knobil, E. Electrophysiological Approaches to the Hypothalamic GnRH Pulse Generator. In: Neuroendocrine Regulation of Reproduction. S.S.C. Yen and W.W. Vale, eds., Serono Symposia, USA, 1990, pp. 3-8.
  • 193. Williams, C.L., J-C. Thalabard, K.T. O’Byrne, P.M. Grosser, M. Nishihara, J. Hotchkiss and E.Knobil. Duration of phasic electrical activity of the hypothalamic gonadotropin-releasing hormone pulse generator and dynamics of luteinizing hormone pulses in the rhesus monkey. Proc. Natl. Acad. of Sciences. 87:8580-8582, 1990.
  • 194. O’Byrne, K.T., J-C. Thalabard, P.M. Grosser, R.C. Wilson, C.L. Williams, M-D. Chen, D. Ladendorf, J. Hotchkiss and E. Knobil. Radiotelemetric monitoring of hypothalamic gonadotropin-releasing hormone pulse generator activity throughout the menstrual cycle of the rhesus monkey. Endocrinology. 129:1207-1214, 1991.
  • 195. Knobil, E. Foreword. In: Perspectives in Primate Reproductive Biology. N. R. Moudgal, K. Yoshinaga, A.J. Rao and P.R. Adiga (eds.) Wiley Eastern Limited, 1991.
  • 196. Knobil, E. Remembrance: The discovery of the hypothalamic gonadotropin-releasing hormone pulse generator and of its physiological significance. Endocrinology 131(3):1005-1006, 1992.
  • 197. Chen, M-D., K.T. O’Byrne, S.E. Chiappini, J. Hotchkiss and E. Knobil. Hypoglycemic “stress” and gonadotropin releasing hormone pulse generator activity in the rhesus monkey: Role of the ovary. Neuroendocrinology. 56:666-673, 1992.
  • 198. Grosser, P.M., K.T. O’Byrne, C.L. Williams, J-C. Thalabard, J. Hotchkiss and E. Knobil. The effects of naloxone on estrogen-induced changes in hypothalamic gonadotropin-releasing hormone pulse generator activity in the rhesus monkey. Neuroendocrinology. 57:115-119, 1993.
  • 199. O’Byrne, K.T., M-D. Chen, M. Nishihara, C.L. Williams, J-C. Thalabard, J. Hotchkiss and E. Knobil. Ovarian control of gonadotropin hormone-releasing hormone (GnRH) pulse generator activity in the rhesus monkey: Duration of the associated hypothalamic signal. Neuroendocrinology. 57:588-592, 1993.
  • 200. Knobil, E. The GnRH pulse generator: Past, Present and Future. In: GnRH, GnRH Analogs, Gonadotropins and Gonadal Peptides. P. Bouchard, A. Caraty, H.J.T. Coelingh, Bennink and S. N. Pavlou (eds.) Parthenon Publishing, London, 1993.
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  • 201. Knobil, E. and K.T. O’Byrne. Electrophysiological approaches to GnRH pulse generator activity in the rhesus monkey. Human Reproduction. 8:37-40, 1993.
  • 202. Knobil, E. Editorial: Inhibition of LH secretion by fasting and exercise: “Stress” or specific metabolic signals? Endocrinology. 132:1879-1880, 1993.
  • 203. Cardenas, H., T. ?rd?g, K.T. O’Byrne and E. Knobil. Single unit components of the hypothalamic multiunit electrical activity associated with the central signal generator that directs the pulsatile secretion of gonadotropic hormones. Proc. Natl. Acad. of Sciences. 90:9630-9634, 1993.
  • 204. O’Byrne, K.T., J-C. Thalabard, S.E. Chiappini, M-D. Chen, J. Hotchkiss and E. Knobil. Ambient light modifies gonadotropin-releasing hormone pulse generator frequency in the rhesus monkey. Endocrinology. 133:1520-1524, 1993.
  • 205. Hotchkiss, J. and E. Knobil. The menstrual cycle and its neuroendocrine control. In: The Physiology of Reproduction. Second Edition, E. Knobil and J. D. Neill (eds.) Raven Press, 1994.
  • 206. O’Byrne, K.T. and E. Knobil. Electrophysiological analysis of GnRH pulse generator activity in the rhesus monkey. In: Methods in Neuroscience – Pulsatility in Neuroendocrine Systems, Jon E. Levine (ed.), Academic Press, 1994.
  • 207. Knobil, E. Some modulations of GnRH pulse generator activity in the rhesus monkey. In: Ovulation Induction – Basic Science and Clinical Advances. M. Filicori and C.Flamigni, (eds.). Excerpta Medica International Congress Series. Elsevier Sciences Publishers, Amsterdam, 1994.
  • 208. Ordog, T. and E. Knobil. Estradiol and the inhibition of hypothalamic gonadotropin-releasing hormone pulse generator activity in the rhesus monkey. Proc. Natl. Acad. of Sciences. 92:5813-5816, 1995.
  • 209. Knobil, E. A propos du contr?le du cycle menstruel et de l’ovulation. Contracept. Fertil. Sex. 23:705-709, 1995.
  • 210. Chen, M-D., T. ?rd?g, K.T. O’Byrne, J.R. Goldsmith, M.A. Connaughton, and E. Knobil. The insulin hypoglycemia-induced inhibition of gonadotropin-releasing hormone pulse generator activity in the rhesus monkey: roles of vasopressin and corticotropin-releasing factor. Endocrinology. 137:2012-2021, 1996.
  • 211. Knobil, E. Doctoral education in the biomedical sciences: Back to the future? Academic Medicine. 71:871-875, 1996.
  • 212. Ordog, T., M-D Chen, M. Nishihara, M.A. Connaughton, J.R. Goldsmith, and E. Knobil. On the role of gonadotropin-releasing hormone (GnRH) in the operation of the GnRH pulse generator in the rhesus monkey. Neuroendocrinology. 65:307-313, 1997.
  • 213. Ordog, T., M-D Chen, K.T. O’Byrne, J.R. Goldsmith, M.A. Connaughton, J. Hotchkiss, and E. Knobil. On the mechanism of lactational anovulation in the rhesus monkey. Am. J. Physiol. Endocrinol. Metab. 37:E665-E676, 1998.
  • 214. Knobil, E. In Memoriam: Roy Orval Greep. Endocrinology. 139:4026-4028, 1998.
  • 215.Knobil, E. In Memoriam: Roy Orval Greep. J. Clin. Endocrinol. Metab. 83:3381-3383, 1998.
  • 216. Knobil, E. In Memoriam: Roy Orval Greep. Mol. Endocrinol. 12:1463-1465, 1998.
  • 217. Chen, M-D, T. ?rd?g, and E. Knobil. Mitigation of the somnolence of insulin-induced hypoglycemia by a vasopressin V1 receptor antagonist in the rhesus monkey. Psychoneuroendocrinology. 23:497-503, 1998.
  • 218. ?rd?g, T., J.R. Goldsmith, M-D Chen, M.A. Connaughton, J. Hotchkiss, and E. Knobil. The Wisdom of the Body Revisited: The 1997 Walter B. Cannon Memorial Lecture. News in Physiological Sciences, 14:1-11, 1999.
  • 219. Knobil, E. Regulation of gonadal activity in the primate and in the human. (French) Bull. Mem. Acad. R. Med. Belg. 154:7-9, 1999.
  • 220. Nakai Y., Plant, T.M., Hess, D.L., Keogh, E.J., Knobil, E. On the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion in the rhesus monkey. 1978. Am. J. Obstet. Gynecol, 193:1764-1765, 2005.
  • 221. Knobil, E. Discovery of the hypothalamic gonadotropin releasing hormone pulse generator and of its physiologic significance. 1992. Am. J. Obstet. Gynecol. 193:1765-1766, 2005.
  • BOOKS
  • 1. Knobil, E. and W.H. Sawyer. (eds.) The pituitary gland and its neuroendocrine control. Handbook of Physiology, Section 7, Volume IV, Part 1 and 2. The American Physiological Society, Washington, D.C., 1974.
  • 2. Knobil, E. and J.D. Neill. (eds.) The Physiology of Reproduction. Volume I and Volume II. Raven Press, First Edition, 1988 and Second Edition, 1994.
  • 3. Knobil, E. and J.D. Neill. (eds.) Encyclopedia of Reproduction. Volumes I-IV. Academic Press, 1998.
  • 4. Knobil, E. and J.D. Neill. (eds.) Knobil and Neill’s Physiology of Reproduction. Volume I and Volume II Elsevier, Third Edition, 2006.

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Detailed Description/Box and Folder Listing

Series I: Personal and Education
This series contains material such Dr. Knobil’s curriculum vita, biographical information, bibliography, list of fellows and students, photographs, family letters and information about academic positions for which he applied or was recruited. In addition there is material such as a high school yearbook, self-portrait in graphite, college and graduate school class notebooks, his PhD thesis, and his appointment to Dr. R.O. Greep’s lab as a post-graduate.
1 1 Curriculum vita and biographical information.
1 2 Obituaries and tributes.
1 3 List of Postdoctoral Fellows.
1 4 List of Research Data Books.
1 5 Bibliography.
1 6 Letters to parents, 1942-1956. 1 of 2.
1 7 Letters to parents, 1942-1956. 2 of 2.
1 8 Photographs. 1 of 2.
1 8 Photographs (from Series II: Harvard years). 2 of 2.
1 10 Correspondence: Hotchkiss, Mrs. E.B.
1 11 Hotchkiss Knobil, Julane: resignation letter, passport copies, curriculum vita.
1 12 Position offers.
1 13 Positions (1950s).
1 14 Press clippings.
1 15 Bettendorf book: Biographical information.
2 1 1942 Haaren High school yearbook, drawing and notebook.
2 2 College and graduate school: Biochemistry, 1948.
2 3 College and graduate school: Comparative Anatomy, 1948.
2 4 College and graduate school: Zoology 2.
2 5 College and graduate school:Animal Husbandry 125.
2 6 College and graduate school: Chemistry III.
2 7 College and graduate school: Lectures in Endocrinology, Prof. S.L.Leonard, Spring 1950.
2 8 College and graduate school: Genetics, Biochemistry, Zoology.
2 9 College and graduate school: Physiology 14 laboratory notes, Fall term 1949.
3 1 College and graduate school: Reference Manual for Animal Breeding.
3 2 College and graduate school: Miscellaneous data. (2 notebooks not in folder.)
3 3 College and graduate school: Chemistry III.
3 4 College and graduate school: Botany 124.
3 5 College and graduate school: Physiology lectures and demonstrations.
3 6 College and graduate school: Entomology, Paper, April 29, 1947.
3 7 College and graduate school: Embryology, 1943.
3 8 College and graduate school: Biochemistry 203.
4 1 College and graduate school:Zoology, Spring 1950.
4 2 College and graduate school: Biochemistry 203.
4 3 College and graduate school: Soils.
4 4 College and graduate school: Biochemical genetics.
4 5 College and graduate school: Physiology.
4 6 College and graduate school: Endocrinology.
4 7 College and graduate school: Biochemistry, Fall 1948.
4 8 Beta-glucuronidase Activity and Tissue Growth: Cleveland AAAS meeting, 28 December 1950.
4 9 College and graduate school: Thesis: The Relation of some steriod hormones to the B-Glucuronidase activity in the accessory organs of reproduction, 1951.
4 10 Post-doctoral appointment with R.O. Greep.

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Series II: Harvard years 1951-1961
This series contains material such as correspondence, meeting, manuscripts and class material written during the time Dr. Knobil was associated with Harvard University. The order established by Dr. Knobil was maintained, except that material in some folders was combined into single folders.
1 1 Appointment notification to Assistant Professor of Physiology, 1956.
1 2 Correspondence: American Society of Zoologists.
1 3 Correspondence: Armour Labs (Steelman); Endocrine Study Section Hormones; Preston L. Perlman (Schering Corp.).
1 4 Correspondence: Society for Endocrinology.
1 5 Correspondence: Seiffer, Joseph; Amoroso, E.C.; Barnes, R.H.; Penick, George; Wilson Laboratories.
1 6 Correspondence: Wolff, Carl; Belardo, Joseph; Wilff, Jan; Clewe, Thomas; Weston, J.K.
1 7 Correspondence: American College of Physicians (talk, May 10, 1961); Upjohn.
1 8 Correspondence: Brook Lodge Conference 1958, 1961.
1 9 Correspondence: American Physiological Society.
1 10 Correspondence: Society for Experimental Biology and Medicine; American Associaiton of Anatomists.
1 11 Correspondence: Reid, Duncan; Reid, Eric; Romney, Seymour.
2 1 Endocrine Lab and Lecture outlines, 1960.
2 2 Area 1, 1960.
2 3 Genetics: 1958-1959, Medical HG and D.
2 4 Exercise 25, 1958-1959: Hormone unknown.
2 5 Harvard telephone directory, 1961.
2 6 Appointments: University business.
2 7 Hormones and Vitamins: Munson and Hirsch.
2 8 Committee Financial Aid to Medical Students: 1958-1959.
2 9 MS Stimulation of Leucene-2-C14 incorporation into protein of diaphragm by simian GH in vitro.
2 10 Goldberg, R.C.
2 11 Colloquia: Brown University, 1961.
2 12 Conforerence Growth: Purdue, June 16-18, 1960.
2 13 Conference: Control of Ovulation, February 26-28, 1960.
2 14 Conference: Physiological Mechanisms Concerned with Conception, July 29-31, 1959.
2 15 First International Congress on Endocrinology.
3 1 Conference on the Uterus, February, 1958.
3 2 Physiology of the Pituitary Gland post grad course in Internal Medicine, 1959.
3 3 Lipemia Seminar, 1957.
3 4 Post grad course in Gynecology, 1959.
3 5 Lecture: Post-grad course in Gynecology, 1957-1958.
3 6 American College of Physicians talk, April 9, 1957.
3 7 Hall, Dr. Sam; Harlow, Dr. Harry F.
3 8 Direct evidence for fatty acid mobilization.
3 9 DCA in monkeys.
3 10 Laurentian manuscript. 1 of 2.
3 11 Laurentian manuscript. 2 of 2.
3 12 Kostyo and Knobil: Effect of GH on in vitro incorp of Leucine into diaphragm.
3 13 McGinty, D.A.; Mead-Johnson; Miscellaneous.
3 14 Growth Hormone Symposium, 1954.
3 15 International Physiological Congress, 1956.
3 16 Eli Lilly.
3 17 Laurentian Hormone Conference, 1959: notes.
3 18 Monkey pituitaries and monkey pictures (negative).
3 19 Monkeys.
4 1 Monkey data: Adrenal.
4 2 Lipids: Pregnancy data. 1 of 2.
4 3 Lipids: Pregnancy data. 2 of 2.
4 4 Fetal adreanal manuscript.
4 5 Serum electrolytes in the hypophysectomized Rhesus monkey manuscript.
4 6 Effect of a primate pituitary growth hormone preparation on nitrogen metabolism in the hypophysectomized Rhesus monkey manuscript.
4 7 Competitive inhibition manuscript.
4 8 Laurentian Hormone Conference.
4 9 Ovary Pictures.
4 10 Markle Foundation. 1 of 3.
4 11 Markle Foundation. 2 of 3.
4 12 Markle Foundation. 3 of 3.
4 13 Consultants in Physiology, 1959.
5 1 Fellows, Students: Brande, Paul.
5 2 Fellows, Students: Franklin, M.J.
5 3 Fellows, Students: Goodman, Maurice.
5 4 Fellows, Students: Hotchkiss, Julane.
5 5 Fellows, Students: Josimovich, John B.
5 6 Fellows, Students: Markovitch, Jack H.
5 7 Forth, Jacob; Engel, Frank L.; Fischer, John.
5 8 Endocrine Dinner Club; The Dinner Club.
5 9 Diczfalusy, Egon; Bergenstal, D.M.; Berry, Dean George P.; Best, G.R.
5 10 Hoffman, F.G.
5 11 Houssay, Bernardo A.; Jones, I. Chester.; Korner, A.; Huggett, A. St. G.; Johnson, F.H.
5 12 CIBA.
5 13 Miscellaneous Correspondence 1960- .
5 14 Miscellaneous 1961.
5 15 Miscellaneous Correspondence.
5 16 Merck and Company.
5 17 McArthur, J.A.; Russell, John M.; Paschkis, Karl E.
5 18 Miscellaneous Correspondence 1956.
5 19 John Hopkins University.
5 20 Animal House.
5 21 “The Doctors Who Make Children Grow”, The Saturday Evening Post, June 6, 1959, page 20+.

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Series III: Deanship of the University of Texas Medical School Houston
This series contains information about Dr. Knobil’s tenure as Dean of the University of Texas Medical School Houston (UTMSH), particularly his resignation. This information was kept separate by Dr. Knobil from the information found in Series IV in the folders dealing with the UTMSH.
1 1 For meeting with Frank Morriss. 1 of 2.
1 2 For meeting with Frank Morriss. 2 of 2.
1 3 Speech to UT medical staff after appointment to the Dean’s Office December 7, 1981.
1 4 Term as Dean UTMSH. 1 of 2.
1 5 Term as Dean UTMSH. 2 of 2.
1 6 UTMSH: Deanship information.
1 7 Congratulatory letters: Dean’s appointment.
1 8 Testimonials EK (UTMSH Deanship resignation).
1 9 Personal correspondence (copies of resignation letter included).
1 10 For meeting with Dr. Bulger.
2 1 Correspondence with Roger J. Bulger 1984.
2 2 Correspondence with Roger J. Bulger November 1983-December 1983.
2 3 Correspondence with Roger J. Bulger July 1983-October 1983.
2 4 Correspondence with Roger J. Bulger to July 1983.
2 5 Miscellaneous: 1981 calendar; January 6-8, 1981 Itinerary; 1 letter, 1 card from Roger J. Bulger; letter of appointment, June 11, 1982.

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Series IV: General Files
This series contains general files, such as correspondence, meeting material and lectures from the 1960’s – 2000. The alphabetical order established by Dr. Knobil was maintained. Folder labels were transcribed as shown on original folders, except that acronyms for organizations were spelled out and that some individual files (due to size) were combined within the General Files. Ernst Knobil is frequently abbreviated EK. Post-doctoral fellows are noted in parentheses as post-doc, however not all fellows are shown. For a complete list of fellows, students and associates see Series I, Box 1.
1 1 General Files: A miscellaneous.
1 2 Abstracts (not complete).
1 3 Academic Medicine: EK’s article – summer, 1996.
1 4 Akema, Tatsuo (post-doc).
1 5 American Academy of Arts and Sciences: 2000 Election, Nominations, etc.
1 6 American Academy of Arts and Sciences: Member, Class II Membership Committee May 1998-May 2000.
1 7 American Academy of Arts and Sciences.
1 8 American Gynecological and Obstetrical Society.
1 9 American Medical Association.
1 10 American Men and Women of Science.
1 11 American Physiology Society.
1 12 American Physiology Society: Honorary Membership Committee.
1 13 American Physiology Society: Endocrine Section.
1 14 American Physiology Society: History Book Advisory Committee Associate Member 5/1/98-4/30/2001.
2 American Physiology Society Plaque: recognition of Dr. Knobil as President
2 1 American Physiology Society: History Advisory Committee, Dr. Giuseppe Sant’Ambrogio.
2 2 American Physiology Society: History Book Manuscript.
2 3 American Physiology Society: White Paper – Draft and published (written by EK August 1990).
2 4 American Physiology Society: Constitution and Bylaws October 1988.
2 5 Association of American Medical Colleges.
2 6 Association of American Medical Colleges: Advisory Panel on Biomedical Research (APBR) Graduate Research, Educaiton and Training (GREAT).
2 7 Association of American Medical Colleges.
2 8 Attardi, Barbara (post-doc.
3 1 General Files: B miscellaneous. 1986-1995. 1 of 2.
3 2 General Files: B miscellaneous. 1986-1995. 2 of 2.
3 3 General Files: B miscellaneous. 1996-.
3 4 General Files: B miscellaneous.
3 5 Barraclough, C.A.
3 6 Baulieu, Etienne-Emile.
3 7 Baylor College of Medicine, miscellaneous.
3 8 Belchetz, Paul E. (post-doc).
3 9 Bergman, Richard N.
3 10 Buja, Louis Maximillian.
4 1 Bulger, Roger.
4 2 Burke, Thomas.
4 3 Burroughs Welcome Fund.
4 4 Byrne, John H.
4 5 General Files: C miscellaneous
4 6 Cameron, Judy.
4 7 Cardenas , Hugo (post-doc)
4 8 Castro, Gilbert A.
4 9 Chen, Jia-Lun.
4 10 Chen, Ming-dao (post-doc).
4 11 Chen, Yu.
4 12 “Classic Pages” Essay for American Journal of Obstretrics and Gynecology (EKs writeup).
5 1 Commencement Address University of South Alabama, 1985.
5 2 Committee of Periodic Review of Tenured Faculty.
5 3 Connaughton, Martin (post-doc).
5 4 Courses: Reproductive Biology: Advanced-Fall 1999; Introductory-Jan-Apr. 1998-1999.
5 5 Courses: Mammalian Physiology: Endocrine/Metabolism Section 1999, 1998, 1996.
5 6 Courses: Physiology 1997, 1995.
5 7 General File: D miscellaneous.
5 8 Detre, Thomas.
5 9 Dierschke, D.J. (post-doc).
5 10 Doctors Club
5 11 Dufy, Bernard. (post-doc).
6 1 General Files: E, miscellaneous.
6 2 Encycolpedia of Reproduction. Academic Press. General Correspondence. 1 of 4.
6 3 Encycolpedia of Reproduction. Academic Press. General Correspondence. 2 of 4.
6 4 Encycolpedia of Reproduction. Academic Press. General Correspondence. 3 of 4.
6 5 Encycolpedia of Reproduction. Academic Press. General Correspondence. 4 of 4.
6 6 Encycolpedia of Reproduction. Contracts, Payments, etc.
6 7 Encycolpedia of Reproduction. Topics Lists and Authors Lists.
7 1 General File: F miscellaneous.
7 2 Franchmont, Paul.
7 3 Franco-US Seminar on Scientific and Technological Cooperation.
7 4 Funder, J.W.
7 5 General File: G miscellaneous.
7 6 Germak, John A. (post-doc).
7 7 German Endocrinology Society (Deutsche Gesellschaft fr Endokrinologie) Honorary Member.
7 8 Goldbeter, Albert.
7 9 Goldsmith, Jason Ross. (post-doc).
7 10 Graduate School of Biomedical Sciences.
7 11 Graduate School of Biomedical Sciences: Committee to review Dean – EK appointed chairman 1/1995.
7 12 Graduate School of Biomedical Sciences: Final Report Review Committee.
7 13 Greep, Roy Orval: including material relating to his obituary.
7 14 Grosser, Peter. (post-doc).
8 1 Graduate School of Biomedical Sciences. EK Commencement Address May 13, 1989.
8 2 Guillemin, Roger C..
8 3 General File: H, miscellaneous.
8 4 Halasz, Bela.
8 5 Harvard Search (Wilson, Thomas).
8 6 Hildebrandt, John.
8 7 Hirakawa, Shun (post-doc.
8 8 Honnebier, M. Barbara.
8 9 Hightower, H. Wayne.
8 10 Houston Biotechnology, Inc.
9 1 General File: I miscellaneous.
9 2 International Science Foundation: EK appointed Chair/Biology 2 group.
9 3 International Society of Endocrinology: General Coorespondence. 1 of 2.
9 4 International Society of Endocrinology: General Coorespondence. 2 of 2.
9 5 International Society of Endocrinology: Dr. Lesley Rees, Secretary General.
9 6 International Society of Neuroendocrinology.
9 7 International Union of Physiological Sciences: Commission on Endocrinology. 1 of 2.
9 8 International Union of Physiological Sciences: Commission on Endocrinology. 2 of 2.
9 9 International Union of Physiological Sciences.
9 10 International Union of Physiological Sciences: General Correspondence.
10 1 International Union of Physiological Sciences.
10 2 International Union of Physiological Sciences: EK 1st VP Executive Committee Communications.
10 3 International Union of Physiological Sciences: Communications regarding St. Perterburg Congress. 1 of 2.
10 4 International Union of Physiological Sciences: Communications regarding St. Perterburg Congress. 2 of 2.
10 5 International Union of Physiological Sciences: Miscellaneous and Committees.
10 6 General File: J miscellaneous.
11 1 General File: K miscellaneous.
11 2 Karsch, Fred J. (post-doc)
11 3 Kaufman, Jean Marc (post-doc).
11 4 Kesner, James (post-doc).
11 5 Knobil, Ernst: General Corrrespondence 1980-1983.
11 6 Knobil, Ernst: General Corrrespondence 1984.
11 7 Kostyo, Jack (post-doc); Krey, Lewis C. (post-doc); Kuroda, George (post-doc).
12 1 General File: L miscellaneous.
12 2 Laboratory Meeting Minutes 1986-1990.
12 3 Laboratory Meeting Minutes 1980-1985.
12 4 Laboratory Meeting Minutes 1976-1979.
12 5 Laboratory Meeting Minutes 1970-1975.
12 6 Lecture: The Paul Franchimont Memorial Lecture, September 27, 1999, Liege, Belgium.
12 7 Lecture: The Roy O. Greep Lecture, June 15, 1999, San Diego, CA.
12 8 Lecture: Introductory Talk: Reproductive Biology Retreat, May 24, 1999, M.D. Anderson.
12 9 Lecture: Cannon Lecture: April 6, 1997, New Orleans, LA.
12 10 Lecture: Miscellaneous.
12 11 Lecture: XXXIII International Congress of Physiological Sciences, June 26-July4, 1997, St. Petersburg, Russia (cancelled).
12 12 Lecture: Tenth Bowditch Lecture 1966(?).
13 1 Lecture: Scientific Lectures 1974-1978.
13 2 Lecture: Organon Lecture, September 19, 1987.
13 3 Lecture: French Lecture, April 20, 1988, Symposium: Les Gonadotrophines, April 20-22, 1988.
13 4 Lecture: University Claude Bernard, May 16, 1990, Lyon, France.
13 5 Lecture: University of Bordeaux II, May 21, 1990.
13 6 Lecture: 23rd French Congress on Fertility and Sterility, Presidential Address November 11, 1995.
13 7 Lecture: Belgium Royal Academy of Medicine, September 25, 1999, Brussels, Belgium.
13 8 Lecture: Miscellaneous Opening Remarks.
13 9 Lecture: Association of American Medical Colleges Council of Deans Education for Medicine: The Continuing Crisis, March 21, 1985.
13 10 Leonard, Samuel.
13 11 Leon, Donald F.
13 12 Little, Brian.
14 1 General File: M miscellaneous.
14 2 Macy, Jr., Josiah, Foundation.
14 3 Mark, Hans.
14 4 Marshall, Gary (post-doc)
14 5 Martini, Luciano.
14 6 McCann, S.M.
14 7 McGrath, M.J.
14 8 Mellon Foundation New York.
14 9 Moenter, Suzanne.
14 10 Morriss, Frank H.
14 11 Muller, Eugenio.
14 12 Murad, Ferid.
14 13 General File: N miscellaneous.
14 14 Nader, Shala.
14 15 Nakai, Yoshikatsu (post-doc).
14 16 NASA.
15 1 National Academy of Sciences: 1997-.
15 2 National Academy of Sciences: 1994-1996.
15 3 National Academy of Sciences: 1986-1993.
15 4 National Academy of Sciences: Invitation; Pledges/Dues.
15 5 National Academy of Sciences: Committee on International Organizations and Programs.
15 6 National Academy of Sciences: Commission on Human Rights.
15 7 National Academy of Sciences: Newly elected members congratulation letters.
15 8 National Academy of Sciences: Lang/Huntington issue.
15 9 National Academy of Sciences: Institute of Medicine.
15 10 National Academy of Sciences: National Research Council; Report Review Committee .
15 11 National Academy of Sciences: Institute for Laboratory Animal Research: Report Review Committee .
16 1 National Academy of Sciences: Section 23, Election of Members (Member of Nominating Committee.
16 2 National Academy of Sciences: Section Liaison Report/Summaries.
16 3 National Academy of Sciences: Committee on Hormonally Active Agents in the Environment. 1 of 6.
16 4 National Academy of Sciences: Committee on Hormonally Active Agents in the Environment. 2 of 6.
16 5 National Academy of Sciences: Committee on Hormonally Active Agents in the Environment. 3 of 6.
16 6 National Academy of Sciences: Committee on Hormonally Active Agents in the Environment. 4 of 6.
16 7 National Academy of Sciences: Committee on Hormonally Active Agents in the Environment. 5 of 6.
17 1 National Academy of Sciences: Committee on Hormonally Active Agents in the Environment. 6 of 6.
17 2 National Academy of Sciences: “On Being a Scientist” (keep for distribution to new post doctoral research fellows)
17 3 National Academy of Sciences: Proceedings.
17 4 National Academy of Sciences: Proceedings/Tony Plant.
17 5 National Hormone and Pituitary Program.
17 6 National Institute of Child Health and Human Development.
17 7 National Medal of Science (EK nominated by UT-Houston May 1996).
17 8 Neill, Jimmy D. (post-doc).
17 9 News in Physiological Sciences.
18 1 Nishihara, Masugi (post-doc).
18 2 General File: O miscellaneous.
18 3 O’Bryne, Kevin (post-doc).
18 4 Ordog, Tamas (post-doc).
18 5 Ordre des Palmes Academique.
18 6 Oulu, University of.
18 7 General File: P miscellaneous.
18 8 Pang, Songja.
18 9 Pappenheimer, John.
18 10 Pardo, Ricardo. (post-doc)
18 11 Pfaff, Donald W.
19 1 Plant, Tony M. (post-doc)
19 2 Pohl, Clifford R. (post-doc)
19 3 Press Conference, Wednesday, March 22, 1978.
19 4 Quabbe, H.J.
19 5 General File: R miscellaneous.
19 6 Reviews: The Physiology of Reproduction, 1st edition.
19 7 Raven Press (Lippincott Willimas and Wilkins) The Physiology of Reproduction.
19 8 Raven Press: The Neuroendocrine Control of the Menstrual Cyle in: The Physiology of Reproduction. 1 of 3.
19 9 Raven Press: The Neuroendocrine Control of the Menstrual Cyle in: The Physiology of Reproduction. 2 of 3.
19 10 Raven Press: The Neuroendocrine Control of the Menstrual Cyle in: The Physiology of Reproduction. 3 of 3.
20 1 Ribble, John.
20 2 Rosner, Jorge.
20 3 Ross, Griff T.
20 4 General File: S miscellaneous. 1 of 2.
20 5 General File: S miscellaneous. 2 of 2.
20 6 Sabbatical Leave – Bordeaux 6/81-12/81 (Planned French Sabbatical).
20 7 Sakuma, Maki (post-doc).
20 8 Sanborn, Barbara M.
20 9 Schally, Andrew V.
20 10 Schultz, Stanley.
20 11 “Science”: Letter, August, 1996.
21 1 Searle Scholars Program.
21 2 Sell, Stewart.
21 3 Shapiro, Alvin P.
21 4 Short, Roger.
21 5 Simian B Virus.
21 6 Silverman, Ann.
21 7 Society for Study of Reproduction.
21 8 Speech: “Charles Eucharist de Medici Sajous and the Adrenal Glands” to Baylor History of Medicine Class, 1989.
21 9 Stancel, George M.
21 10 Steinberger, Anna; Steinberger, Emil.
22 1 General File: T miscellaneous.
22 2 Talwar, G.P.
22 3 Tanddon, O. P.
22 4 Thalabard, Jean-Christophe. (post-doc) 1 of 2.
22 5 Thalabard, Jean-Christophe. (post-doc) 2 of 2.
22 6 Turek, Fred W.
22 7 General File: U miscellaneous
22 8 Uemura, Tsuguo (post-doc).
22 9 University of Pittsburgh, School of Medicine, Department of Physiology, Annual Report.
22 10 University of Pittsburgh, (confidential information re: compensation).
23 1 University of Pittsburgh, 1970; John Hopkins, 1968; Reproduction Lecture material (?).
23 2 University of Pittsburgh, Lecture notes (?).
23 3 University of Pittsburgh, Principles of Mammalian Physiology.
23 4 University of Texas Medical Branch.
23 5 University of Texas Medical School-Houston: Animal Research.
23 6 University of Texas Medical School-Houston: Department of Integrative Biology.
23 7 University of Texas Medical School-Houston: Department of Physiology and Cell Biology.
23 8 University of Texas Medical School-Houston: Physiology Final Exam May 16, 1994.
23 9 University of Texas Medical School-Houston: Interview Medical School Applicants. Restricted unless student names are redacted.
24 1 University of Texas Medical School-Houston: Report Challenges of Extended Space Flight.
24 2 University of Texas Medical School-Houston: Associate Dean for Management; Committees.
24 3 University of Texas Medical School-Houston: Laboratory for Neuroendocrinology Annual Reports, 1994, 1995, 1996, 1998, 1999 (1997 missing).
24 4 University of Texas Medical School-Houston: Medical School’s Objectives Committee – 1998.
24 5 University of Texas Medical School-Houston: History Project, 1998. (Interview with Bryan Boutwell).
24 6 University of Texas Medical School-Houston: General Correspondence.
24 7 University of Texas Medical School-Houston: Neuroscience Research Center.
24 8 University of Texas Medical School-Houston: Department of Obstetrics, Gynecology and Reproductive Sciences.
25 1 University of Texas Medical School-Houston: Problem Based Learning 1999-2000.
25 2 University of Texas Medical School-Houston: Problem Based Learning 1998-1999.
25 3 University of Texas Medical School-Houston: Problem Based Learning Exam Questions.
25 4 University of Texas Medical School-Houston: Photographs of School and three Deans; plaque.
25 5 University of Texas Medical School-Houston: Problem Based Learning.
25 6 University of Texas Medical School-Houston: Research Committee 1996-200 (Minutes and Agendas).
25 7 University of Texas Medical School-Houston: Student Advisor (1994-1996); Mentor Program Summer Research Program.
25 8 University of Texas Medical School-Houston: Program in Reproductive Biology.
26 1 University of Texas Medical School-Houston: Training Program in Mammalian Reproduction (GSBS).
26 2 University of Texas Medical School-Houston: Women’s Reproductive Health Research Career Development Center and Scholars Program; Texas Women’s Reproductive Health Consortium.
26 3 University of Texas Medical School-Houston: Department of Surgery.
26 4 University of Texas Health Science Center-Houston: General Correspondence and Memos 1984-1987.
26 5 University of Texas Health Science Center-Houston: Housing Information.
26 6 University of Texas Health Science Center-Houston: “Funding Futures”.
26 7 General Files: V miscellaneous.
26 8 Vale, Wylie.
26 9 Vancomycin (Lilly Research Labs).
26 10 Veldhuis, Johannes.
26 11 Vincent, Jean-Didier.
27 1 General File: W miscellaneous. 1 of 2.
27 2 General File: W miscellaneous. 1 of 2.
27 3 Walsh, Scott.
27 4 Werner, Gerhard.
27 5 Wiggins, Richard C.
27 6 Wildt, Ludwig (post-doc).
27 7 Williams, Cynthia L. (post-doc).
27 8 World Health Organization.
27 9 General File: WXZ miscellaneous.
27 10 Yamaji, Tohru (post-doc).
27 11 Yamamoto, Hideki (post-doc).
27 12 Yates, F. Eugene.
27 13 Yerkes Regional Primate Research Center: Advisory Board.

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Series V: Honors and Awards
This series contains information about honors and awards bestowed on Dr. Knobil from national and international organizations and includes press releases or accounts of the recognitions. Some information about his Deanship of the University of Texas Medical School is included.
1 1 Certificates: Cornell University for service to country; Society of the Sigma Xi membership (1951); American Physiological Society (2); National Academy of Sciences (1); American Association fo the Advancement of Science (1).
1 2 The Ernst Knobil Symposium, Pittsburgh, PA, June 10-12, 1994.
1 3 Knobil Research Fellowship.
1 4 American Academy of Arts and Sciences, 1981 certificate.
1 5 Dickson Prize, University of Pittsburgh, Pittsburgh, PA November 25-28, 1989.
1 6 Fred Conrad Koch, 1982.
1 7 National Academy of Sciences.
1 8 National Academy of Sciences: Congratulation notes on EK’s election, April, 1986. 1 of 2.
1 9 National Academy of Sciences: Congratulation notes on EK’s election, April, 1986. 2 of 2.
1 10 National Academy of Sciences: Newspaper articles on EK’s election.
1 11 Who’s Who in Science and Engineering.
1 12 Alpha Omega Alpha (EK elected 5/95).
1 13 Vermuelen Retirement Symposium, Ghent, Belgium September 25-26, 1992.
1 14 Honorary Doctorate, University Bordeaux, October 1981.
1 15 Docteur Honoris Causa, University of Liege, Liege, Belgium.
1 16 Honoris Causa, University of Milan, September, 1999.
1 17 Italian Academy of Sciences.
1 18 Medical College of Wisconsin.
2 1 Hungarian National Academy.
2 2 Officier des Palmes Academiques, July, 1989.
2 3 Comptes Rendus: Member, Editiorial Board of official journal of French Academy, 1993-1997.
2 4 French Academy of Science, elected Foreign Associate Member, 1989.
2 5 Belgian Royal Academy of Medicine, elected Foreign Member 1997.
2 6 Axel Munthe Award, Capri, Italy, September 27-29, 1985.
2 7 Accolades/Professional Biographical Information. 1 of 3.
2 8 Accolades/Professional Biographical Information. 2 or 3.
2 9 Accolades/Professional Biographical Information. 3 or 3.
2 10 Ashbel Smith Professorship, Regent approval June, 1989.
2 11 Professor Emeritus, notes.
2 12 Faculty Profile (University of Texas Medical School – Houston.
2 13 University of Texas Health Science Center – Houston, Presiden’t Scholar.

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Series VI: Grants and Financial Reports 1953-1996
This series contains information about grant applications and supporting material. Computer generated grant ledgers and other records, except for 1996 to serve as a sample of such records, were discarded.
1 1 Grant Application: Table of applications 1953-1996; Table of National Institutes of Health award amounts 1983-1996. Note: Original file label (e.g. 6c, 6d) is shown on some of the labels in this series. The table of applications should be used to correlate the current folder to the original.
1 2 Grant Application: National Institutes of Health, PHS-NIH A-292 Number 1.
1 3 Grant Application: National Institutes of Health, PHS-NIH A-292 (C1) and (C2) Number 2.
1 4 Grant Application: National Institutes of Health, PHS-NIH A-292 (C3), (C4), (C5), (C6), (C7).
1 5 Grant Application: National Institutes of Health, PHS-NIH A-503 and A-503 (c).
1 6 Grant Application: National Institutes of Health, PHS-NIH A-503 (C2).
1 7 Grant Application: National Institutes of Health, PHS-NIH A-503 (C3).
1 8 Grant Application: National Institutes of Health, PHS-NIH A-503 (C4), (C5).
1 9 Grant Application: William F. Milton Fund (Harvard University).
1 10 Grant Application: American Cancer Society EDC-18.
1 11 Grant Application: American Cancer Society EDC-18A and 18B.
1 12 Grant Application: American Cancer Society Institutional Grant. (6c, 6d).
1 13 Grant Application: American Cancer Society Institutional Grant. (6e).
1 14 Grant Application: American Cancer Society Institutional Grant P-139 and P-139A. (7a, 7b, 7c).
1 15 Grant Application: The Upjohn Company. (8).
1 16 Grant Application: The Ford Foundation 65-57A, 65-57B. (9a).
2 1 Grant Application: The Ford Foundation 65-57 and 650-0057B and 650-0057C. (9b, 9c).
2 2 Grant Application: The Ford Foundation 65o-0057E. (9d).
2 3 Grant Application: The Ford Foundation. (9e).
2 4 Grant Application: National Institutes of Health T01 GM 1404. (10).
2 5 Grant Application: National Institutes of Health HD 16615-01. (11).
2 6 Grant Application: National Institutes of Health HD 08610 and HD08610-07. (12-1).
2 7 Grant Application: National Institutes of Health HD 08610 and HD 08610-07. (12-2).
2 8 Grant Application: National Institutes of Health HD 03968 and 03968-22. 1 of 2. (13a-2).
3 8 Grant Application: National Institutes of Health HD 03968 and 03968-22. 2 of 2. (13a-2).
3 2 Grant Application: National Institutes of Health HD 03968 and 03968-22. (13a-3).
3 3 Grant Application: National Institutes of Health HD 17438-02 and HD 17438-03. (13b1, 13b2).
3 4 Grant Application: National Institutes of Health HD 17538-04 and HD 17438-05. (13c1, 13c2).
3 5 Grant Application: National Institutes of Health HD 17438-06. (13c3).
3 6 Grant Application: National Institutes of Health HD HD 17328-07, HD 17438-08, HD 17438-09, HD 17438-10, HD 17438-11. (13d1-13g). 1 of 2.
3 7 Grant Application: National Institutes of Health HD HD 17328-07, HD 17438-08, HD 17438-09, HD 17438-10, HD 17438-11. (13d1-13g). 2of 2.
3 8 Grant Application: National Institutes of Health HD HD 17328-12, HD 17438-13, HD 17438-14, HD 17438-15. (13k-n).
4 1 Grant Application: A.W. Mellon Foundation. (14a, 14b).
4 2 Grant Application: Center for Primate Reproduction. (15).
4 3 Grant Application: P-30 progress reports. (16).
4 4 Grant Application: Senior International Fellowship Application. (17)
4 5 Grant Applications: Miscellaneous NIH stuff… (18)
4 6 Grant Applications: Ledgers: University of Texas Health Science Center-Houston.
4 7 Grant Applications: Advanced Research Program.
4 8 Grant Applications: 1954-1959 miscellaneous.
5 1 Financial Information: General 1996-2000 Lab for Neuroendocrinology.
5 2 Financial Records: Lab Account 1EK-2-8545 FY1996. (1 of 3).
5 3 Financial Records: Lab Account 1EK-2-8545 FY1996. (2 of 3).
5 4 Financial Records: Lab Account 1EK-2-8545 FY1996. (3 of 3).
5 5 Financial Records: Hightower FY93.
5 6 Grants: Ellwood Foundation.

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Series VII: Reprints and Manuscripts
This series contains reprints or copies of Dr. Knobil’s publications. Many of the original reprints were destroyed or severely damaged in a flood in 2001 and were discarded. As of September 13, 2007, all items (except four) listed in Dr. Knobil’s Bibliography are either available in this collection as reprints or copies or at the Houston Academy of Medicine-Texas Medical Center Library. Four items are not available through these sources, but are available through Inter-library Loan from other medical libraries in the United States. A Bibliography in Box 1 of this series indicates which items are in this collection.
Manuscripts or reprints may be filed with other material in this collection, especially in Series II and IV.
1 1 Reprints: Bibliography.
1 2 Reprints: 1950s.
1 3 Reprints: 1960s. 1 of 2.
1 4 Reprints: 1960s. 2 of 2.
1 5 Reprints: 1970s.
1 6 Reprints: 1980s.
1 7 Reprints: 1990s.
2 1 Manuscript: International Life Sciences Institute Conference on Human Diet and Endocrine Modulation, 1988
2 2 Manuscript: On the Mechanism of the Positive Feedback Action of Estradiol on LH Secretion in the Rhesus monkey.
2 3 Manuscript: The Wisdom of the Body Revisited (The Cannon Lecture).
2 4 Manuscript: The Circhoral Hypothalamic Clock that Governs Reproduction. (Submitted to Neuroscience Research Center Newsletter – 4/15/95; Noted: Do Not Add to EK’s CV.)
2 5 Manuscript: Lutrepulse Sumposium Manuscript: The GNRH Pulse Generator. (Reprinted from a contribution to Control of the Onset of Puberty; Noted: Not added to EK’s CV at his request.)
2 6 Manuscript: Organismic Physiology: The New Frontier in Claude Bernard and the Internal Environment…
2 7 Manuscript: Unpublished.
2 8 Manuscript: Early Papers (1950s).

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Series VIII: Calendars
This series contains calendars kept by Dr. Knobil and by his office staff.
1 1 Calendars: 1955, 1956, 1957.
1 2 Calendars: 1958, 1959, 1960.
1 3 Calendars: 1961, 1962, 1963.
1 4 Calendars: 1964.
1 5 Calendars: 1981, 1985.
1 6 Calendars: 1982-1987, Travel.
1 7 Calendars: 1988-1991, Travel.

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Series IX: Travel
This series contains information about the travel Dr. Knobil made in 1962-1963, 1981-1988, and 1999 and travel logs kept by his secretary for years 1982-1991. The records of trips were combined into years; a table with the original folder title information was made and the original folders discarded. There is material such as conference schedules, Dr. Knobil’s personal schedules and some correspondence about the trips. Receipts, such as flight and taxi costs, were discarded.
1 1 Travel logs 1982-1991. Travel information taken from original folder labels.
1 2 India trip 1962-1963.
1 3 Houston, 1981.
1 4 1982.
1 5 1983. 1 of 2.
1 6 1983. 2 of 2.
1 7 1984.
2 1 1985. 1 of 2.
2 2 1985. 2 of 2.
2 3 1986.
2 4 1987. 1 of 3.
2 5 1987. 2 of 3.
2 6 1987. 3 of 3.
3 1 1988. 1 of 5.
3 2 1988. 2 of 5.
3 3 1988. 3 of 5.
3 4 1988. 4 of 5.
3 5 1988. 5 of 5.
3 6 1999.

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Series X: Research Data (Laboratory Notebooks) 1951-1997
This series contains the laboratory data books used by Dr. Knobil and his team. They are catagorized by study, in the order in which they were sent to the Archive, and labeled according to an inventory which accompanied them. No other processing was done on any of the material in this series. Note: Boxes 71 – 85 were damaged in a flood. Because of the damage the contents of these boxes were in most cases, of necessity, separated into two boxes. For example, Box 71 and Box 71-A contain the material that was originally only in one box.
1 Adrenalectomy in the rhesus monkey: Box 1 of 2
Harvard School of Dental Medicine, and Department of Physiology, Harvard Medical School. Collaborators and fellows: R.O. Greep, R.C. Wolf, M.J. Fregley, F.G. Hofmann Book A and Book B, (1951-1953). Monkey experiments, Na and K determinations, books Ia, Ia and II (1954-1955) Methods used (1951-1961, Harvard)
2 Adrenalectomy in the rhesus monkey (continued): Box 2 of 2
Na collection books I-IV, (1955-1956). Ascorbic acid and adrenal function book (1954).
3 Endocrine function in pregnancy, and other studies
Department of Physiology, Harvard Medical School. Collaborators and fellows: J.B. Josimovich, F. N Briggs, R.C. Wolf Thyroid and pregnancy, and insulin and pregnancy (1956-57). Anterior pituitary transplants (into the eye) (1951). ZZB vs S. Webb cholesterol method. Rat adrenal cholesterol determinations (1954). Pregnancy and hypophysectomy (1953-1955). Fetal thyroids and livers, Pregnant and nonpregnant PBI’s, fetal thyroid radioactive iodide uptake, effect of hypophysectomy and adrenalectomy on fetal adrenal weight, ascorbic acid, and cholesterol. Rat log book I (1956) Monkey fetal organs (1959) Prolactin assay (pigeon crop sac bioassays) (1957) Looseleaf folder: Hypophysectomy and crude pituitary extracts: effect on follicular development, with photographs. Typed notes
4 Lipemia of pregnancy:
Department of Physiology, Harvard Medical School. Collaborators and fellows: H.M. Goodman, J.L. Kostyo Lipemia of pregnancy in the rat, Books 1-4 (1956-1957). Rat pregnancy NEFA, Expt 1-22 ( 1959-1960). Plasma NEFA and fat pad NEFA release Lipemia of pregnancy in the monkey, Books 1 and 2 (1956-1960) (book 1 contains first monkey FFA data, see also Box 10) Ketones.
5 Growth Hormone: Species Specificity and Metabolic Actions: Box 1 of 9
Department of Physiology, Harvard Medical School. Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: R.O. Greep, R.C. Wolf, J.L. Kostyo, P.F. Brande, H.M. Goodman, J. Hotchkiss, M.J. Franklin, W.D. Peckham, G.R. Fritz, B. Katorski Zain, J.B. Josimovich, R.J. Schimmel, P. Lebovitz, H. Friesen, H. W. Sokol, R.K. Black Monkey experiments, nitrogen determination by microKjeldahl method (1953-54) Growth hormone infusion tests (1954-56) Acute GH “A” Monkey Book I (1953-54) Monkey Book II (1954…) Daily log books 1 (1955-56), 2 (1956-58), 3 (1958-60) Prolactin
6 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 2 of 9
Monkey experiments: Glucose tolerance tests, insulin tolerance tests, anesthesia tests Book 1 (1952-54); Book 2 (1954-55); Book 3 (1955-58); Book 4 (1955-58), Book 5 (1958-61). Hypoglycemic effects of simian growth hormone (1958-59)
7 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 3 of 9
Nitrogen data, book I (1955-56); book II (1956-57); book III (1957); book IV (1957-58). Growth hormone assay, (1955…) Bovine and monkey growth hormone preparations 35Sulfate incorporation into costal cartilage of rats and monkeys (the effects of plasma from growth hormone-treated animals) (1958) Monkey survey – summary of GH treatments to all animals (1954….) Experiment 25: (1956) nature unknown.
8 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 4 of 9
In vivo CO2 determination, Book I (1958-59): Whole animal CO2 production from the oxidation of palmitate-1-14C in fed, fasted, normal, ad thyroidectomized rats ? growth hormone treatment, Experiments 1-48; Book II, Experiments 49-58, first rat NEFA. In vitro oxidation of fatty acids to 14CO2, ? growth hormone treatment, Book I (1959-60) Experiments 1-21; Book II, (1960..) Experiments 22-26, also effects of GH added in vitro ? amino acids on glucose uptake by adipose or diaphragm tissues, experiment 1-7, and Effects of T3 on palmitate oxidation by kidney from thyroidectomized animals (to 1964). Free fatty acids in monkey plasma, Book 1 (1958) Experiments 1-22 are in Box 4 in the back of the Lipemia of pregnancy in the monkey book; Book 2 (1958-) Experiments 28-81; Book 3 (1958-59), Experiments 82-147. GH (porcine, monkey, etc.) treatment; Book 4 (1959-1960), Experiments 148-175,
9 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 5 of 9
Protein synthesis, Book I (1959-60), effect of primate and bovine growth hormone on glycine- or phenylalanine- 2-14C incorporation into the hemidiaphragms of hypophysectomized rats, Book II (1960); Book III (1960), Book IV (1960), Book V (1961) Amino acid incorporation and transport.
10 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 6 of 9
Tissue NEFA release, ? GH, ? prolactin, ? corticotropin, ? TSH, ? epinephrine,? pituitrin, Books I-VI, (1958-1960) Growth in guinea pigs (1957-58)
11 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 7 of 9
Growth in guinea pigs (1958-60) (Harvard Medical School) GH (in vitro) effects in guinea pigs (1962-65) (University of Pittsburgh School of Medicine) SPACE
12 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 8 of 9
Growth Hormone Action (amino acid transport) Book I (1961),; Book II (1961-62); Book III (1962); Book IV (missing??); Book V (1962-64); Book VI (1962-63) AIB transport Book I (1962-63) Summary of placental AIB transport studies, AIB transport in rat hemidiaphragms, Book II (1963); Book III (1964) AIB transport in the pregnant monkey.
13 Growth Hormone: Species Specificity and Metabolic Actions (continued): Box 9 of 9
Monkey FFA and Growth Hormone: (1963-1968) Testing hGH, bGH and GH hydrolysates Transport and incorporation of amino acids (P. Lebovitz), (1965..) Looseleaf folders (Lebovitz) Testing the similarities between ovine placental lactogen (oPL) and growth hormone on the rise in NEFA in rhesus monkey (1975-76, H. Friesen)
14 Regulation of GH secretion in the rhesus monkey: Box 1 of 5
Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: V. Meyer, M. Sakuma, M.H. Taylor, R. Guillemin, A.V. Schally, W.D. Peckham, Radioimmunoassay of growth hormone, Books 1-6 (1963-64). HGH = human growth hormone, sGH = simian growth hormone.
15 Regulation of GH secretion in the rhesus monkey (continued): Box 2 of 5
Radioimmunoassay of growth hormone, Books 7-9 (1964-1965). Regulation of GH in feeding, fasting, insulin hypoglycemia, pitressin, pig hypothalamic extracts, cortical extracts, epinephrine, estrogens
16 Regulation of GH secretion in the rhesus monkey (continued): Box 3 of 5
Looseleaf folders: Summary data from 1965 and 1966, experiments with crude and purified hypothalamic extracts, GRF, etc., Letters to and from A.V. Schally re GRF (1965-67), Notes, letters and paper from Solomon A Berson re radioimmunoassay
17 Regulation of GH secretion in the rhesus monkey (continued): Box 4 of 5
Radioimmunoassay of growth hormone, Books 10-14: Book 10 (1965-66) hemorrhage, estrogens, thyroidectomy and T4 treatment, pig hypothalamic factor, ACTH, pitressin, purified Schally GRF, chlorpromazine, nembutal, Book 11 (1966) nembutal ? pitressin, stress, histamine, hemorrhage and nembutal, lys-8-vasopressin and nembutal, insulin ? Nembutal, pitressin ? nembutal, fasting human SME (Schally); Book 12 (1966) pitressin ? GRF (Schally); human SME and GRF, nembutal/morphine, sound-proof box; Book 13 (1966-1967) morphine/nembutal ? insulin or epinephrine, nembutal + insulin, or pitressin, or human SME, or pig SME, or sheep SME., histamine, etc.; Book 14, GRF with morphine/nembutal, ACTH (1967) Charcoal Book 1: assays 66-79. Change of method (1966).
18 Regulation of GH secretion in the rhesus monkey (continued): Box 5 of 5
Radioimmunoassay of growth hormone, Books 15-18. Book 15 (1967-68), GH to hypophysectomized monkeys; Book 16 (1968-69) hGH, fasting and cortisone on FFA; Book 17 (1968-69) Fasting, GH infusion, insulin or pitressin during hGH infusion; Book 18 (1969-1970) pitressin ? hGH infusion, Guillemin GRF, electrical stimulation, Guillemin TRF ?? GH injection book, (1967) radioactive hGH injection into 4 hypophysectomized monkeys. Charcoal book 2 91969-1970). GH methods.
19 Lab meeting minutes and protocols
Department of Physiology, University of Pittsburgh School of Medicine. Collaborators and fellows: see Fellows list Folder #1: 1969-1971, #2: 1972-1974, #3: 1975-1977, #4: 1978-1980, #5: 1981- 1982(June). Looseleaf folder: Laboratory Methods and Procedures, University of Pittsburgh School of Medicine, 1961-1981. Resuscitation after cardio-pulmonary arrest (date?); Blood sampling in the infusion lab, 1981; Preparation of GnRH bottles for use with peristaltic pumps, 1980; Maintenance of Xonis independent automatic film processor (date?); Procedures for operating the dental X-ray unit (1978); Infusion lab procedures with peristaltic pump; changing GnRH bottles and pump line assemblies, (1980); Pump and timer check-p (1980); Treatment of lesioned or stalk-sectioned animals during and after surgery, (1978, 1980); Ovariectomy of the rhesus monkey, (date?); Drugs and doses, (1977, 1980); Bleeding duties (date?); Admission to animal laboratories, (date?). Steroid Hormone Radioimmunoassays, Radioimmunoassay of Rhesus monkey Pituitary Gonadotropins. Book: First attempt at LH bioassay, 1966-1967, JD Neill. And second attempt at LH bioassay, 1977 (testosterone production assay) (all in one book)
20 Gonadotropin Radioimmunoassay Development 1965-1972: Box 1 of 3
Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: J.D. Neill, S.E. Monroe, L.E. Atkinson, A. Bhattacharya, J.K. Datta, T. Yamaji, W.D. Peckham Ovine LH, simian LH, human LH, simian FSH, Prolactin. Folder: Ovine LH Radioimmunoassays 1-13, 1967. Simian LH Radioimmunoassays: Book I, assays 1-40 (1966-1968); II, assays 41-44 (1968). III (missing, no book found). IV, assays 52-64 (1969…). LH Radioimmunoassay Book I, September through December, 1965, Assays 1-11.
21 Gonadotropin Radioimmunoassay Development 1965-1972 (continued): Box 2 of 3
LH Radioimmunoassay Book II, December, 1965 -April 1966, Assays 12-23A LH Radioimmunoassay Book III, April 1966-March, 1967, Assays 25-49. Human LH Radioimmunoassay Book IV, 1967. Assays 65-72. FSH Radioimmunoassay , Book I. 1966-1968. Assays 1-13.
22 Gonadotropin Radioimmunoassay Development 1965-1972 (continued): Box 3 of 3
Radioimmunoassay of rhesus FSH, 1970, Assays 78-94? Radioimmunoassay of Gonadotropins I 1970?, Assays 99B-117E. Includes FSH, LH, prolactin Radioimmunoassay of Gonadotropins II, to 1972. Assays 118-154. Radioimmunoassay techniques, 1969-1971.
23 Steroid Radioimmunoassay Development , 1966-1973: Box 1 of 4
Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: A.H. Surve, J.D. Neill,. J. Hotchkiss, E.D.B. Johansson, F.J. Karsch, R.L. Goodman Progesterone (1966-70). Book I: 1966 Protein-binding method of Murphy. 6/28/66 and on. . No numbered books follow. Some seem to be missing. Assays 1-65 1969: Surve I..CBG; 1969, Surve II;1969-1970; Progestins;. 1970 Surve IV
24 Steroid Radioimmunoassay Development, 1966-1973 (continued): Box 2 of 4
Progesterone (1970-80). 170: first column chromatography of steroids. 1970-1971: Column chromatography of steroid books, + specifics on 3H-steroids up to 1980. 1970: Progesterone “quickies”, progesterone assays, 1971-1973: Progesterone RIA
25 Steroid Radioimmunoassay Development, 1966-1973 (continued): Box 3 of 4
(1966-1973): Testosterone Radioimmunoassay, 1971-1972. Progesterone RIA; 1973 17?-progesterone RIA, 1972 Estrogen Radioimmunoassay, Book 1, 1966-1967. Book II, 1967
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26 Steroid Radioimmunoassay Development, 1966-1973 (continued): Box 4 of 4
Estrogens (1967-80). Estrogen RIA (1967-69) Metabolic clearance rate of estradiol, Books 1 and 2
27 Regulation of Gonadotropin Secretion: (30 books, 1968-1982). Box 1 of 10
Department of Physiology, University of Pittsburgh School of Medicine Collaborators and fellows: D.J. Dierschke, J.D. Neill, L.C. Krey, W.R. Butler, A. N. Bhattacharya, L.E. Atkinson, F.J. Karsch, R. Weick, R. Guillemin, D.L. Hess, R.L. Goodman, Y. Nakai, G. Weiss, F.J. Karsch, E.J. Keogh, P.E. Belchetz, L. Wildt, J.K. Datta, J.T. McCormack, A.H. Surve, E.D.B. Johannson, B. Attardi, J. Hotchkiss, H.P. Schane, S.L. Monroe, M.H. Taylor, T. Yamaji, T. Akema, T. Uemura, F. Piva, T.M. Plant,, J. H.-K. Lu, B. Dufy, L. Dufy-Barbe, B. Attardi, G.R. Marshall, G.R. Fritz, A. Hausler, E. Schallenberger, J.S. Hutchison, C.R. Pohl, J.A. Germak, D.W. Richardson, J.S. Kesner, R. C. Wilson, L.T. Goldsmith, J. Resko, J. Espinosa-Campos. labeled #101-129 + #110a, 1968-70. I: (#101). 1968-1969. LRF injection, postovariectomy gonadotropin rise, effects of estradiol benzoate treatment, LH fluctuations during the day in ovariectomized monkeys (first circhoral oscillations of LH) II: (#102). 1969. Effects of histamine, Na pentobarbital, chlorpromazine, haloperidol on LH secretion III: (#103). 1969-1970. Circhoral oscillations of LH, effects of estradiol, progesterone, testosterone, chlorpromazine, phentolamine, ?-methylparatyrosine, phenoxybenzamine, dopamine… on LH secretion IV: (#104). 1970. Propranolol, castrate males, use of estradiol benzoate to induce the LH surge, and the effects of drugs on the EB-induced surge V: (#105). 1970. Effects of estradiol and testosterone in castrated male monkeys, effects of drugs and natural LH surge, estradiol in the luteal phase, LH in intact males and the effects of EB, steroid levels in steroid-implanted animals
28 Regulation of Gonadotropin Secretion, continued: (30 books, 1968-1982). Box 2 of 10
VI: (#106). 1970. Description of steroid implants and blood levels of steroids, progesterone blockade of the EB-induced LH surge in intact females and the timing thereof, effect of fluoxymestrone or DHT on LH in ovariectomized monkeys, in vivo conversion of testosterone, DHT or fluoxymestrone to estradiol in ovx monkeys, effect of porcine LRF on LH levels, phenoxybenzamine blockade of the LH surge, surge induction with estradiol implants, EB in the luteal phase, positive and negative feedback effect of estrogen in castrates, EB dose response and LH surge induction, effects of scopolamine or propranolol on the EB induced surge VII: (#107). 1970. See book 106. EB induction of surge in young and lactating monkeys, effects of phenoxybenzamine or propranolol in ovx monkeys, progesterone blockade of the LH surge in ovx monkeys, effects of castration on LH levels in the male, attempts to induce the LH surge with EB in intact males, circhoral oscillations in castrate males. VIII: (#108) see book 107. Luteectomy, during lactation, in chaired animals, in immature females. Effects of ovariectomy in the immature female. Circhoral oscillations in intact and castrate males, and in recent castrates (mature and immature). IX: (#109). 1970-1971. See book # 108. Frequency sampling at midcycle. Timing of ovulation by ovum recovery. Effect of testosterone on LH in intact adult males. Effect of EB in immature males, and in castrate males.
29 Regulation of Gonadotropin Secretion (continued): (30 books, 1968-1982). Box 3 of 10
X: (#110). 1971. Repeated induction of the LH surge with EB in female monkeys (normal, and during lactation, and in immatures). Response of immature animals to estradiol implants and their removal. EB induction of the LH surge in postpubertal female monkeys. In castrate females: effects of chronic phentolamine, rate of rise of circulating estradiol after implantation, effect of ovariectomy of the immature monkey on LH rise, post-castration rise of LH in an estradiol-implanted monkey, effects of testosterone infusion, effect of LRF in estradiol-implanted ovx monkeys, effects of estradiol infusion. In Males: Effect of DHT in the acutely castrated male, effects of castration in the baby male, effect of EB, or of estradiol infusion, in castrated males Xa: (#110a). 1969-1971.Short feedback mechanisms and LRF experiments: hCG, OLH, LH, LRF XI: (#111). 1971. See book # 110. Frequent sampling in the follicular (early and late), midcycle, and luteal phases. Effects of progesterone in estradiol-implanted ovx animals, LH levels in the ovx-adrenalectomized monkey, effect of DHT in the ovx monkey, long-term negative feedback. XII: (#112). 1971, Progesterone and blockade of the LH surge in intact and ovx monkeys. Guillemin LRF studies, lactation studies. Strength-duration studies in ovx animals using estradiol implants. EB-induced LH surges in castrated estradiol-implanted male monkeys.
30 Regulation of Gonadotropin Secretion (continued): (30 books, 1968-1982). Box 4 of 10
XIII: (#113). 1971, Guillemin LRF in intact females, strength-duration studies (continued), pituitary autotransplants trials, induction of the LH surge in pubertal and prepubertal female monkeys (Davis experiment), effect of ?-methylparatyrosine on EB-induced LH surges. Ovx monkeys: effects of chlorpromazine, , LH receptors, long-term negative feedback, threshold of estradiol for LH surge (strength-duration studies), EB-induced surges in intact male monkeys. XIV: (#114). 1971-19712. Strength-duration studies, LRF, ovulation timing by ovum recovery, EB in menarchial monkeys (Population Council experiment), Effect of TRF on prolactin in postpartum, follicular, and luteal phases, Effect of ?-methylparatyrosine in ovx monkeys, LRF, refractoriness to repeated surge attempts in progesterone-treated monkeys, 5?-androstane-3?,17?-diol; kinetics of release from an implant. Regulation of Gonadotropin Secretion XV: (#115). 1972. Induction of puberty studies (will 5?-androstanediol or progesterone induce puberty in immature females?) LRF, Strength-duration studies, estrone and estradiol in the CSF. In castrate females: effect of estradiol levels on the responsiveness to LRF. ?-methylparatyrosine, TRH, phenoxybenzamine or EB on LH, FSH and prolactin, Effect of TRH in ovx monkeys. In males: Positive and negative feedback in castrates with estradiol implants, LRF in castrated males., testosterone levels in castrate males with T implants. XVI: (#116). 1972. Strength/duration studies, TRF, positive and negative feedback in pregnancy, EB in menarchial animals (Population Council), neurophysin infusion, gonadotropin levels in ovx-adrex animals, pituitary content of LH and FSH during and after the LH surge.
31 Regulation of Gonadotropin Secretion (continued): (30 books, 1968-1982). Box 5 of 10
XVII: (#117). 197112-1973. Stress and the LH surge, LRF in the follicular phase, LH in ovulation timing studies, scopolamine and the EB-induced surge, L-DOPA and gonadotropin secretion, prolongation of the luteal phase progesterone level and gonadotropin secretion, effect of chronic nembutal and the EB -induced surge. In ovx animals: scopolamine, 5-hydroxytryptophan, 17?-hydroxyprogesterone, dexamethasone, phenoxybenzamine, prolonged pentobarbital or morphine, pituitary LH and FSH content. In males: diurnal variation in testosterone, effect of testosterone propionate on LH secretion in the castrate. XVIII: (#118). 1973. EB studies in Population Council animals. Prolonged pentobarbital and LH surge, refractory period, effects of thyroidectomy on TSH secretion, thyroid and adrenal weights, p-chlorophenylalanine, reserpine, L-DOPA effects, induction of the LH surge with chlorpromazine. In ovx animals: scopolamine, induction of the LH surge in ovx-adrex animals, effects of the withdrawal of cortone acetate in the ovx-adrex animal. In males: diurnal variations in testosterone in T-implanted castrates, LRF in intact males. Regulation of Gonadotropin Secretion XIX: (#119) 1973-1974. Supersuppression of TSH with thyroxin, blockade of surge with reserpine, chronic scopolamine, does rabbit-15 immunoassayable material (LH-like material) rise when rhesus LH fails to? (in immature, lactating, ovariectomized females, or immature males). Thyroid collection. Split stimulus: estradiol and progesterone. Does elevated estradiol cause premature parturition? CB154 in the luteal phase, luteotrophic effect of prolactin (protocol). Acute scopolamine or morphine, LH after acute estradiol benzoate, LRF pulses and haloperidol, serum estrone levels after estrone implant. In males: Testosterone dynamics in the castrate, gonadotropins in castrate immature males, estradiol and testosterone variations in intact males, effect of testosterone on tonic LH secretion.
32 Regulation of Gonadotropin Secretion (continued): (30 books, 1968-1982). Box 6 of 10
XX: (#120). 1974-1975. Depot TRF effect on circulating prolactin, and its effect on the EB-induced surge in intact females, estradiol implants and studies of rebound, effect of progesterone on rebound, biochemical characteristics of the LH secreted during the surge. Effect of CB154 on CL function. Ovx animals: AntiLHRH dosimetry, effect of progesterone on the EB-induced in estradiol-implanted animals. In males: estradiol implants and circulating estradiol levels in castrates, T and DHT implant details, T and estradiol replacement immediately after castration in adult males. XXI: (#121). Pimozide and prolactin, antibodies to neurophysin B: effect on gonadotropin secretion. CB154 and the luteal phase. Production of TSH and Prl-free sera. EB effects on LH and LRH in peripheral blood (male and female). Effect of CB154 and ovine Prl on CL function. Effect of anti-LHRH and CB154 on the LH surge. In ovx animals: Effect of Koch antiserum on LH and FSH secretion. Is there a diurnal rhythm in the LH surge?(EB at 0900 and 2100 hrs). Effects of 2-OH-estradiol and 17?-estradiol on circhoral LH secretion. XXII: (#122). 1975-1977. Time course of estradiol after estradiol cipionate or lab-made estradiol benzoate. Half-life of LHRH in vivo. Testing of lab-made EB solutions and the protocol of making estradiol benzoate in oil. XXIII: (#123). 1976-1977. Effect of oxytocin on the EB-induced LH surge, estradiol antagonists: nafoxidine (Ull,100A) and tamoxiphen (ICI 46,4764)..will they induce an LH surge? In ovx monkeys: effect of progesterone on the EB-induced surge in ovx animals chronically implanted with estradiol implants. Does nafoxidine have any estrogenic activity? Effect of phentolamine on LH and prolactin secretion in pentobarbital-sedated ovx monkeys.
33 Regulation of Gonadotropin Secretion (continued): (30 books, 1968-1982). Box 7 of 10
XXIV: (#124). 1977-1979. Mechanism of action of estradiol in the regulation of gonadotropin secretion in the ovx monkey: Study of pituitary cytosol and nuclear estradiol receptors. Protocol, 1977. XXV: (#125). Remote sampler studies. XXVI: (#126). John Resko, 1978-1979. Effects of progesterone on androstenedione concentrations in the circulation of the female rhesus monkey. XXVII: (#127). 1980. Follicular phase rises in estradiol in intact females (days 5-15). Regulation of Gonadotropin Secretion XXVIII: (#128). 1980. Mechanism of the progesterone-blockade on the estradiol-induced surge…continuous GnRH as a mechanism for the progesterone blockade. XXIX: (#129) Gonadotropin secretion in cynomolgus monkeys XXX: (130) Cabling and suppression of LH in ovariectomized monkeys, (1981-1982) Regulation of TSH secretion in the monkey; 1974-1975
34 Regulation of Gonadotropin Secretion (continued): (1968-1982) Box 8 of 10
Looseleaf Folder 1: Effect of hypophysectomy on corpus luteum function (1966-1967), with Polaroid pictures of ovaries. Looseleaf Folders 2 and 3: Ovulation induction with Pergonal in hypophysectomized animals, with Polaroid pictures (1967-1968)
35 Regulation of Gonadotropin Secretion (continued) : (1968-1982) Box 9 of 10
Looseleaf folder: Follicular development, with Polaroid slides, 1969 Looseleaf folder: Hypophysectomy, hysterectomy, and early progesterone data, 1966- 1967. Looseleaf folder: HCG treatment, 1968-1969. Looseleaf folder: Maintenance of adrenalectomized monkeys with implants of 9?-fluorohydrocortisone acetate. looseleaf folders:
36 Regulation of Gonadotropin Secretion (continued): (1968-1982) Box 10 of 10
Looseleaf Folder 1: Rhesus monkey menstrual cycle data: LH, FSH, estradiol, progesterone, and follicular development, (1968-1970). Looseleaf folder 2: Abnormal menstrual cycles, 1969-1970
37 Regulation of Corpus Luteum Function: Box 1 of 3
Department of Physiology, University of Pittsburgh School of Medicine labeled and others. Collaborators and fellows: G. Weiss, F.H. Karsch, W.R. Butler, D.J. Dierschke, K. Inskeep, L.E. Atkinson, J..Hotchkiss, G.R. Fritz, E.D.B. Johansson, J.K. Datta, G. Weiss, L.C. Krey and others CL Book 1 (#651) 1970-1971. X-irradiation of monkey ovaries to destroy follicles.Effects of injected estrogens or estradiol implants in the luteal phase on the length of the menstrual cycle and on progesterone secretion. Effect of estradiol implants on the hCG rescued corpus luteum. CL of pregnancy. CL Book 2 (#652). 1972… Effect of antiestrogens (ICI 46,474, U11,100A) on CL lifespan. mechanism. Estrogen content of the CL ? hCG treatment. CB154 studies (dosage, volume). CL of pregnancy and lactation. CL book 3 (#653). 1973-1979. CL estrogen secretion patterns, Steroid content of CL and of ovarian venous drainage, Effects (and dosimetry) of the implantation of androstenetrione (ATD, aromatase inhibitor) in the luteal phase and on midfollicular levels of estradiol and LH and in ovx animals, in vitro studies of CL function, effects of low doses of nafoxdine (U11,100A) on CL lifespan. Steroid content of CL and ovaries (1972-1975) Also homogenization and estradiol content of the MBH Book: Rescue of the corpus luteum by chorionic gonadotropin, 1970. Book with graphs.
38 Regulation of Corpus Luteum Function (continued): Box 2 of 3
Looseleaf folders: (old “book” 602) Keith Inskeep data: Ovarian and uterine vein prostaglandins and steroids, luteal steroid content, peripheral blood steroids and gonadotropins, pituitary gonadotropin contents, 1975 etc, Steroid content of the active and inactive ovary during the early and late follicular phase, midcycle, and early, mid and late luteal phase (CL isolated from remainder of ovary). Some with ovarian venous blood and peripheral blood steroids. SPACE
39 Regulation of Corpus Luteum Function (continued): Box 3 of 3
Studies on Pregnancy in the Rhesus Monkey (1967-71). Book: Gonadotropins and sex steroids during pregnancy in the rhesus monkey, 1969-1970 Looseleaf folder: Periovulatory progesterone and cortisone or ACTH treatment, ovariectomy in pregnancy, 1967-1968 Looseleaf folder: Chronic hCG treatment (1968), acute hCG treatment, “Reinius” data and correspondencee reperiimplantationn histology, Fertile and nonfertile cycle progesterone levels (1970-1971), Looseleaf Folder : Monkey pregnancy data (1969-1971). LH, rCG, estrone, estradiol progesterone Looseleaf folder 4: More pregnancy data
40 The Control of Puberty in the Rhesus Monkey
Department of Physiology, University of Pittsburgh School of Medicine labeled and others. Collaborators and fellows: G.R. Fritz, D.J. Dierschke, F.J. Karsch, T.M. Plant, J. Germak, D.W. Richardson, and others Book 500: 1973-1975. Surgical manipulations and the onset of puberty. The effect of estradiol benzoate in inducing LH/FSH surges in the immature monkey. Complete MBH disconnection and development of the positive feedback EB-induced gonadotropin surge. Protocol. Book 501: 1967-1977. Long-term Puberty Studies, Book I. Hormonal profiles of monkeys born in 1967, 1970, 1971 and 1972. Book 502: Long-term Puberty Studies, Book II. Continuation of Book 501. Book 503: Induction of puberty with LHRH treatment, 1977-1978, Polaroid pictures. No book 504 found Book 505, same as book 503 but with revised protocol. 1978-1979. Book 506, Puberty Studies, Book I, 1978-1979. Control of gonadotropin secretion in neonatal females. Book 507, Puberty Studies, Book II, 1979… Does exogenous estradiol hasten maturation of the positive feedback in GnRH treated prepubertal and postpubertal monkeys? See also Hypothalamic Control of Gonadotropin Secretion series, studies in immature animals….
41 Hypothalamic Regulation of Reproductive Function:
Pituitary stalk section, Halasz cuts, aspiration lesions (1971-1981) Box 1 of 2 Department of Physiology, University of Pittsburgh School of Medicine labeled and others. Collaborators and fellows: L.C. Krey, D.L. Hess, T.M. Plant, F.J. Karsch, W.R. Butler, R.F. Weick, M. Ferin, L. Wildt, P.E. Belchetz, Y. Nakai, and others Book 421, 1971-1973. Stalk section, hypothalamic lesions, Halasz cuts in the ovariectomized and intact monkey, effects of 17?-estradiol on tonic LH secretion in ovariectomized monkeys, frontal deafferentation, complete MBH deafferentation Book 422, Halasz I, 1972-1973. Book 423, Halasz II, 1973. Book 424, Halasz III, 1973-1974.
42 Hypothalamic Regulation of Reproductive Function:
Pituitary stalk section, Halasz cuts, aspiration lesions (continued): (1971-1981) Box 2 of 2 Book 425, Aspiration Lesions, Book I, 1975-1976. Book 425a, Aspiration Lesions, Book II. Brain ablation experiments, “the Big Suck”, in castrate and intact female monkeys, ewes Book 426, Hypothalamic peptides and neurotransmitters, 1977. Very little in here. Studies in stalk-sectioned animals, (done with Michel Ferin at Columbia) Book 607, 1978-1981, and Book 609, 1980-1981. Book 608 is another topic entirely and filed elsewhere. SPACE
43 Hypothalamic Regulation of Reproductive Function:
B. Radiofrequency lesions in the MBH and GnRH replacement (1974-1982)Box 1 of 4 Department of Physiology, University of Pittsburgh School of Medicine labeled and others. Collaborators and fellows: L.C. Krey, D.L. Hess, T.M. Plant, F.J. Karsch, W.R. Butler, R.F. Weick, L. Wildt, P. Belchetz, Y. Nakai, J. Moossy, E.J. Keogh, D.W. Richardson, B. Dufy, L. Dufy-Barbe Book 1 (#301) 1974-1975, preliminary studies in the rat and guinea pig, microlesions, glutamate injection, brain reconstruction (#765), 72-hr LRF infusion Book 2 (#302), 1975. Macrolesions in the MBH and LRF infusions, GH data, thyroxine data, guinea pig and rabbit brains, control sections of the MBH Book 3 (#303), 1975-1976. Lesions continued, repetitive EB challenges, effects on anterior pituitary function Book 4 (#304), 1976-1977. MBH lesions and LRF replacement, pulse/continuous LRF switchover, frequency studies, Protocol Book 5 (#305), 1976-1977. See book 304. Book 6 (#306), 1976-1978. See book 305. Book 7 (#307), 1976-1978. See book 306.
44 Hypothalamic Regulation of Reproductive Function:
B. Radiofrequency lesions in the MBH and GnRH replacement (continued). Box 2 of 4 Book 8 (#308), 1976-1977. See book 307. Book 9 (#309), 1976-1977. See book 308. Also ?-blockers (phentolamine) and estradiol infusion in the intact and ovariectomized monkey. Book 10 (#310), 1977-1981. See book 309. AM/FM study Book 11 (#311), 1977-1978. See book 310. Book 12 (#312), 1977-1979. See book 311. Book 13 (#313), 1977-1978. See book 312. Book 14 (#314), 1978-1979. See book 313. Book 15 (#315), 1978-1979. See book 314. Book 16 (#316), 1979-1980. See book 315. Book 17 (#317), 1979-1980. See book 317. Book 18 (#318), 1979-1981. See book 318. Animal 1070, world champion cycler
45 Hypothalamic Regulation of Reproductive Function:
B. Radiofrequency lesions in the MBH and GnRH replacement (continued):Box 3 of 4 Book 19 (#319), 1979-1981. See book 317. Book 20 (#320), 1980-1981. Methods, GnRH infusion lab, tests of infusion systems, weekly checks of GnRH stocks, pulse volumes delivered, Book 21 (#321), 1979-1981. See book 319. Monkey 689, monkey with Turner’s syndrome Book 22 (#322), 1979-1980. See book 321. Book 23 (#323), 1980-1982. Maintenance of the corpus luteum by the hyperprolactinemia seen with MBH lesions. Protocol, 1980. Book 24 (#324), 1979-1981. See book 323. Book 25 (#325), 1980-1981. See book 324. Book 26 (#326), 1980-1981. See book 325. Book 27 (#327), 1980-181. See book 326. Looseleaf folder: Summary of data on pre- and port-MBH lesion responses to estradiol benzoate, on the progesterone blockade, and on the “GnRH stop” experiments. These data are keyed to the “300 series” books.
46 Hypothalamic Regulation of Reproductive Function:
B. Radiofrequency lesions in the MBH and GnRH replacement (continued): Box 4 of 4 Timers and pumps books (3): 1. 2/9/1978-2/13/1979. 2. 2/14/1979-8/1980. 3. 9/11/80-6/21/1982. Water intake book, 1/4/1975 on. Associated with RF lesions and Halasz cuts. Looseleaf Folder AM/FM data compiled
47 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus. Box 1 of 80 Department of Physiology, University of Pittsburgh School of Medicine labeled and others. Collaborators and fellows: T. Akema, T. Uemura, A. Silverman, R.C. Wilson, B. Dufy, L. Dufy-Barbe, M. Kelly Recording in the Mediobasal Hypothalamus (MBH) Book 451, 1976… Book 452, 1977, # 851 with x-rays Book 453, 19978-1979 Book 454 (this book is missing) Book 455, 1979-1980
48 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 2 of 80 Book 456, 1979-1980 Book 457, 1980 Book 458, 1980, Polaroid pictures Book 459, 1980
49 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued):.. Box 3 of 80 Book 460, 1980-1981 Book 461, 1980-1982 Book 462, 1980-1982 Book 462, 1980-1982 Book 464, Animal 1041, 1980
50 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued):.Box 4 of 80 Book 465, Animals 1265 and 985, 1981-19182 Book 466, Animal 1060, 1980-1981 Book 467, Animals 797, 1252, 1223, 1980-1982 Book 468, Animals 1148, 1180, 1980-1982 Book 469, Animals 1163, 1164 1980-1982
Return to the Table of Contents
51 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 5 of 80 Department of Physiology, University of Pittsburgh School of Medicine and Laboratory for Neuroendocrinology,University of Texas – Houston Medical School Collaborators and fellows: R. Wilson, J. Kesner, J. Hotchkiss, J.-M. Kaufman, J.-C. Thalabard, M.-D. Chen, T. Ordog, Y. Chen, S. Fletcher Chiapinni, C.L. Williams, P.M. Grosser, G. Kuroda, R.R. Pardo, H. Yamamoto, M. Nishihara, K.T. O’Byrne, H. Cardenas, J. Goldsmith, M.A. Connaughton, A. Silverman Animal 1343 (Books 1-4 of 27, 1986-1997, through February, 1990). X-rays, telemetry Fixed electrodes #1 (date?), #2 (date?) telemetry, naloxone ? pentothal, telemetered menstrual cycles, telemetry and estradiol benzoate treatment, follicular, luteal and midcycle time courses
52 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued).Box 6 of 80 Animal 1343 (Books 5-8 of 27, 1990 ). Artificial insemination trials
53 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 7 of 80 Animal 1343 (Books 9-12 of 27, 1990-1992). Hypothalamic monitoring via telemetry throughout pregnancy and postpartum, (baby delivered July 13, 1992)
54 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 8 of 80 Animal 1343 (Books 13-16 of 27, 1992-1993). Telemetry during lactation
55 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 9 of 80 Animal 1343 (Books 17-20 of 27, 1993-1994. Telemetry during lactation, foster mother studies
56 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 10 of 80 Animal 1343 (Books 21-24 of 27, 1994). Telemetry during lactation, foster mother studies
57 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 11 of 80 Animal 1343 (Books 25-27 of 27, 1994-1997). Telemetry during lactation, foster mother studies
58 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 12 of 80 Animal 02 (4 books, 1994-1997). Moveable electrodes #1(date?) . Artificial CSF studies, estradiol capsules, leptin, foster mother.
59 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 13 of 80 Animal 10, (2 books, 1994-1997). Moveable electrodes and icv #1 (1994) Telemetry trial. Animal 241, (2 books, 1995-1997). Moveable electrodes #1(1995); #2 (1995). EGF-R experiment Animal 289, (1 book, 1995-1997). Moveable electrodes #1 (1995). telemetry
60 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 14 of 80 Animal 269, (Books 1-4 of 6, 1995-1997), Moveable electrodes #1 (1995). Telemetry
61 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 15 of 80 Animal 269 (Books 5-6 of 6), Telemetry Animal 275 (2 books, 1995-1997). Moveable electrodes #1 (1995), telemetry Animal 281 (2 books, 1995-1997). Moveable electrodes #1 (1995), telemetry
62 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (contnued): Box 16 of 80 Animal 309 (2 books, 1995-1997). Moveable electrodes #1 (1995), telemetry Animal 329 (2 books, 1995-1997). Moveable electrodes #1 (1995), telemetry, antiestrogen plus estradiol benzoate study
63 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 17 of 80 Animal 399 (2 books, 1995-1997). Moveable electrodes #1 (1995), telemetry Animal 405 (3 books, 1995-1997). Moveable electrodes #1 (1995), telemetry, lactation study (foster mother
64 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 18 of 80 Animal 1400 ( 3 books, 1986-1996). Ovariectomized 1991. Fixed electrodes #1 (1987-1988); #2 (1989); #3 (1989-1996). Volley duration after ovariectomy study, insulin hypoglycemia, effect of light and dark on MUA frequency, telemetry, 17?-estradiol study, estradiol capsules, euthanasia 1996. Animal 1414 (Books 1-2 of 7, 1985-1997). Ovariectomy 1990.Fixed electrodes #1 (1986-1987); #2 (1988-1997). Naltrexone, naloxone, telemetry during the menstrual cycle ? estradiol benzoate treatment, follicular phase and surge time courses, preovulatory progesterone treatment, insulin hypoglycemia, ovariectomy, volley duration changes after ovariectomy.
65 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 19 of 80 Animal 1414 (Books 3-7 of 7). See box 14 for details
66 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 20 of 80 Animal 1471 (Books 1-5 of 7, 1987-1996). Ovariectomy 1992. Fixed electrodes #1 (1987-1990); #2 (1990-1991); #3 (1992-1996) + icv 1993. Naltrexone, long-acting GnRH, pentothal and naloxone, telemetry, ovariectomy, vasopressin experiments, insulin hypoglycemia, telemetry with and without estradiol implant, insulin hypoglycemia, L-NMMA, D-NMMA, ICV volume experiments, osmolality experiments, Prl, osmotic minipumps, antide, NPY-antagonist( PXY-2), anti-AVP + AVP, pituitary saved at euthanasia.
67 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 21 of 80 Animal 1471 (Books 6,7 of 7) 1993-1996. See box 16 for details Animal 1491 (3 books, 1984-1989). Ovariectomized 1984. Fixed electrodes # 1 (1984); #2 (1985); # 3 1985-1989). Estradiol implants, naloxone and estradiol, transmitter tests, CRF experiments, estradiol infusion, naloxone and alcohol, effects of progesterone, AP-5, euthanasia 1989.
68 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 22 of 80 Animal 1493 (4 books, 1984-1989). Ovariectomized 1984. Fixed electrodes #1 (1984-85); #2 1985-1989). Estradiol implants, sleep, pentothal, CRF, NMDA and MK801, morphine, estradiol infusion ? naloxone, naloxone ? alcohol, effect of progesterone on MUA volleys. Animal 1495 (2 books), 1985-1990). Fixed electrodes #1 (1987); #2 (1989-1990). Telemetry trials, telemetry cycles
69 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 23 of 80 Animal 1496 (Books 1-5 of 8, 1985-1995). X-rays. Fixed electrodes #1 (1986-1989); #2(1989.1995). Telemetry cycles ? estradiol), naltrexone and chair stress, pentothal/naloxone, cycle time courses, naltrexone, insulin hypoglycemia (with and without naloxone and with and without dexamethasone pretreatment), BrainWave recording, antiestrogen treatment (ICI 182780), foster mother in lactation study, preparation of prolactin-free serum, euthanasia 1995
70 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 24 of 80 Animal 1496 (Books 6-8 of 8). See box 19 for details Animal 1418 (2 books, 1984-1986?). Ovariectomized (date?). Fixed electrodes #1 (1984-1985); #2 (1985); #3 (1986). Estradiol effects on pulse generator (no MUA). Animal 1441 (1 book, 1982-1984). Ovariectomized 1983. Fixed electrodes #1 (1983-1984. Buserilin, morphine while awake, died 1984.
71 Hypothalamic Regulation of Reproductive Function:
71-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 25 of 80 Animal 843 (2 books, 1982-1985). Ovariectomized 1981. Fixed electrodes #1 (1983-1985). Pentothal, phenoxybenzamine, metoclopramide, yohimbine, phentolamine, acute estradiol infusion, chronic estradiol implant, ethanol. Stress ? estradiol, stress-estradiol-naloxone, estradiol with jacket in cage, died 1985. Animal 1005 (2 books combined into 1, 1982-1993). Ovariectomy 1983. Fixed electrodes #1 (1984-1985). LHRH antagonist, stress/estradiol/jacket, serum donor, died 1993. Animals 1195 and 1069 (in same book). Both were initially used in Pittsburgh. Animal 1195 (See previous records in laboratory notebooks 454(1979)-460(1980) in the “recording in the MBH” series). Head cap removed 1980. Animal 1069 ( to 1982). Ovariectomized 1979. (See previous records in laboratory notebooks 454 (1979)-460 (1980) in the “recording in the MBH” series). First recordings in Pittsburgh (12-18-80). Fixed multielectrode implantation #1 (1981); #2 (1981-1982). First good MUA on 2-11-82. Estradiol half-life under pentobarbital anesthesia. Estradiol effect on MUA. Sacrificed 1982; brain prepared for Dr. Moossy (neuropathologist).
72 Hypothalamic Regulation of Reproductive Function:
72-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 26 of 80 Animal 1127 ( 1 book, 1990-1992). Ovariectomized 1992. Fixed electrodes (1991-1992). MUA changes after ovariectomy, lights on/lights off, foster mother ? telemetry. Died 1992. Animal 1171 (2 books combined into 1, 1985-1989). Ovariectomized 1988. Fixed electrodes #1 (1986); #2 (1987); #3 (1988); #4 (1989). Time course after bromocriptine. Sacrificed 1989. Animal 1191 (1 book, 1982-1983). Ovariectomized 1981. Fixed electrodes #1 (1982) . MUA with pentothal anesthesia and while awake. Electrodes lesioned and sacrificed , 1983. Animal 1206 (3 books combined into 2, 1984-1993). Ovariectomized 1988. Fixed electrodes #1 (1986); #2 (1987); #3 + ICV(1988-1990); #4 (1990-1991); #5 (1992); LH and FSH., pentothal + naloxone, prolactin, CRF ? naloxone, GnRH, estradiol infusion, morphine ? naloxone, AP-5, estradiol implant ? naloxone, given to Fellerman 1993.
73 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 27 of 80 Animal 1218 (2 books combined into one, 1987-1991). Ovariectomized 1988. Fixed electrodes #1 (1987-1991). LH, GH, insulin hypoglycemia ? estradiol, light/dark Animal 1226 (1 book, 1982-1984). Ovariectomized 1982 AND 1983!. Fixed electrodes #1 (1983). Electrodes lesioned and sacrificed 1984. Brain sent to Dr. Silverman. Animal 1228 (1 book, 1984-1986). Ovariectomized 1984. NMR 1985, fixed electrode #1 (1985). Animal 1254 (1 book, 1987-1989). No electrodes. Chronic naltrexone and chairing stress, LH and cortisol. Estradiol administration to mimic midcycle rise. Animal 1264 (1 book, 1982-1983). Ovariectomized 1981. Fixed electrodes #1 (1983). Phenoxybenzamine, metoclopramide, phentolamine, yohimbine, estradiol and stress control, Electrodes lesioned and sacrificed, 1983.
74 Hypothalamic Regulation of Reproductive Function:
74-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 28 of 80 Animal 1269 (books 1-5 of 7, 1984-1994). Ovariectomized 1988. Fixed electrodes #1(1986-1987); #2 (1987-end). Telemetry, CRF, morphine, NMDA, progesterone, insulin hypoglycemia, lights on/lights off, foster mother with telemetry, foster mother ? estradiol implant, BrainWaves study, Estradiol benzoate induced surge in telemetry, euthanasia 1994.
75 Hypothalamic Regulation of Reproductive Function:
75-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 29 of 80 Animal 1269 (books 6,7 of 7). See Box 24 for details. Animal 1271 (3 books, 1982-1984). Ovariectomized 1981. Fixed electrodes #1 (1982). LH, FSH, cortisol, phentolamine, metoclopramide, phenoxybenzamine, yohimbine, acute estradiol, chronic estradiol implant, estradiol and stress, GnRH agonist (buserelin), prazocin, morphine ? naloxone, TRH treatment to raise Prl, GnRH antagonist, ?-endorphin, electrodes lesioned and sacrificed 1984, brain to Dr,. Silverman. Animal 1275 (2 books, 1982-1985). Ovariectomized 1982. Fixed electrodes #1 (1982-1983); #2 (1983-1985). Estradiol and stress and naloxone. Given to Marshak 1985.
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76 Hypothalamic Regulation of Reproductive Function:
76-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 30 of 80 Animal 1286 (1 book, 1982-1983). Fixed electrodes #1 1983. MUA, died 1983. Animal 1287 (3 books, 1985-1988). Ovariectomized 1985. Fixed electrodes #1 (1985-1986); #2 (1986-1987). Estradiol implants and MUA. Animal 1289 (1 book, 1984-1986). Intact. Fixed electrodes #1 (1986). Animal 1293 (1 book, 1984-1985). Ovariectomized 1984. Fixed electrodes #1 (1985). Sacrificed and slides made 1985.
77 Hypothalamic Regulation of Reproductive Function:
77-A C. Electrical recording in the mediobasal hypothalamus (continued) Box 31 of 80 Animal 1304 (books 1-4 of 6, 1985-1990). X-rays included. Fixed electrodes #1 (1986); #2 (1987); #3 (1989 to end). Intact. Telemetry during the cycle, estradiol treatment, progesterone treatment in the follicular phase. Time course during the descending phase of the LH surge. Progesterone in the follicular phase, died 1990.
78 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 32 of 80 Animal 1304 (books 5,6 of 6). See Box 27 for details Animal 1321 (1 book, 1983-1984). Ovariectomized 1983. Fixed electrodes #1 (1983-1984). Buserilin, stress/estradiol/jacket. Sacrificed 1984, blocked and drew MBH. Animal 1322 (3 books, 1983-1986). Ovariectomized 1983. Fixed electrodes #1 (1983-1986). Buserelin, morphine ? naloxone, volley duration and LH pulses, acute and chronic estradiol treatment, MUA volleys during the surge (48 hours), telemetry tests, died 1986.
79 Hypothalamic Regulation of Reproductive Function:
79-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 33 of 80 Animal 1317 (1 books, 1983). Ovariectomized 1983. Fixed electrodes #1 (1983). In her book is a summary of hydrocephalus in implanted monkeys and all that died up to January 18, 1983 and those alive (see p 84 and ff). Animal 1327 (3 books, 1983-1986). Ovariectomized 1983. Fixed electrodes #1 (1983-1986); #2 (1986). Pentothal, prazocin, phentolamine, GnRH agonist, morphine ? naloxone, TRH (high prolactin), metoclopramide, buserilin, chronic estradiol (72 hr estradiol benzoate treatment), video records and MUA, EB-induced surge, died 1986. Animal 1367 (1 book, 1986-1987). Fixed electrodes #1 (1985-1986); #2 (1987). LH and FSH. No good MUA. Animal 1373 (1 book, 1983-1984). Ovariectomized 1983. Fixed electrodes #1 (1984). Lesioned, sacrificed, fix recipe, Silverman histology. Animal 1329 (1 book, 1982-1983). Ovariectomized 1982. Fixed electrodes #1 (1983). Sacrificed after lesioning to see what a good recording site looks like.
80 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 34 of 80 Animal 1391 (1 book, 1982-1985). Ovariectomized 1982. Fixed electrodes #1 (1983). Metoclopramide, yohimbine, TRH(hyperprolactinemia), GnRH agonist, morphine ? naloxone, sacrificed and perfused and brain sent to Dr. Silverman. Animal 1393 (1 book, 1983-1985). Ovariectomized 1983.Fixed electrodes #1(1982). Sacrificed 1985 and perfused and brain sent to Dr. Silverman. Animal 1397 (2 books, 1984-1990). Ovariectomized 1987. Fixed electrodes #1 (1987-1988); #2 (1988), #3 (1988-1990). Time course cage and chair, CRF? naloxone, estradiol implant, morphine ? naloxone, NMDA, died 1990. Animal 1469 (2 books, 1987-1993). Ovariectomized 1991. Fixed electrodes #1 (1989-1990); #2 (1990); #3 (1990-1992). Volley duration after ovariectomy.
81 Hypothalamic Regulation of Reproductive Function:
81-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 35 of 80 Animal 1415 (4 books, 1984-1995). Ovariectomized 1993. Fixed electrodes #1 (1987);#2 (1988-1990); #3 (1990); #4 (1991); #5 (1991-1992); #6 (1992); #7 (1992); #8 (1993, + ICV 1993). Time course in jacket and chair. Telemetry, Effect of CB154 on pulse generator, insulin hypoglycemia, NMLA (not NMDA), BrainWaves, estradiol benzoate induced surge ? naloxone, progesterone Animal 1417 (Book 1 of 6, 1984-1995). Ovariectomized 1984. Fixed electrodes #1 (1984-1985); #2 (1985-1986); #3 (1987-1988); #4 (1988-1991); #5 (1993-1995). Pituitary cannula #1 (1991); #2 (1992). Estradiol implants ? naloxone, NMDA receptor blockade, GnRH antagonist ICV, GnRH, MK801, NMDA antagonist, CRF, morphine ? naloxone, progesterone, insulin hypoglycemia, GABA, push-pull perfusion of pituitary, GnRH metabolic clearance rate, autosampling, euthanasia 1995.
82 Hypothalamic Regulation of Reproductive Function:
82-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 36 of 80 Animal 1417 (books 2-6 of 6). See box 31 for details Animal 1498 (1 book, 1984-1985). Ovariectomized 1984. Fixed electrodes #1 (1984). Antiestrogen studies with LY 117018. Died 1985.
83 Hypothalamic Regulation of Reproductive Function:
83-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 37 of 80 Animal 1486 (3 books, 1984-1989). Ovariectomized 1984. Fixed electrodes #1 (1985-1986), #2 + ICV (1988-1989). E2 implants, long acting GnRH agonist and telemetry. AP5. Sacrificed 11/8/89. Animal 1497 (3 books, 1986-1995). Ovariectomized 1992. Fixed electrodes #1 (1988-1990), #2 (1990-1992), #3 (1993). LH and FSH, NMDA ? MK801. Pituitary perfusion implanted 8/92. Telemetry, estradiol ? antiestrogen, lactation, euthanasia 1995.
84 Hypothalamic Regulation of Reproductive Function:
84-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 38 of 80 Animal 1510 (2 books, 1987-1995). Ovariectomized 1991. Fixed electrodes #1 (1988-1990); #2 (1990-1991); #3 (1992), #4 + ICV (1993-1995). Pituitary push pull cannula #1 (1992), #2 (1992-1993). Volley duration after ovariectomy, E2 capsules, euthanasia 1995. Animal 1514 (2 books, 1990-1995). Fixed electrodes #1 (1990), #2 (1991-1992); #3 (1993-1995). Pituitary push pull cannula #1 (1992-1993). GnRH treatment, foster mother. Euthanasia 1995. Animal 1523 (2 books, 1992-1995). Fixed electrodes #1 (1992-1993). Moveable electrodes #2 (1993-1994), #3 + ICV (1994-). L-arginine and GnRH pulse generator. Foster mother, autosampling. Died 1995.
85 Hypothalamic Regulation of Reproductive Function:
85-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 39 of 80 Animal 1530 (3 books, 1987-1995). Fixed electrodes #1 (1987-1990); #2 (1990-1991); #3 (1991-1992), #4 (1992); #5 (1992-1993); #6 (1993-). Progesterone, telemetry trials, euthanasia 1995. Animal 1535 (1 book, 1992-1994). Ovariectomized 1993. Fixed electrodes #1 (1992); #2 (1993); Moveable electrodes #3 + ICV (1993). Insulin hypoglycemia ? antiCRF, L-NMMA ? antiAVP, Na nitroprusside. Died 1994. Animal 1546 (2 books, 1987-1991). Ovariectomized 1989. Fixed electrodes #1 (1988-1991). Volleys after ovariectomy, progesterone, insulin hypoglycemia ? naloxone ? estradiol capsule. GABA. ICV 1991. Died 1991.
86 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 40 of 80 Animal 1570 (1989-1990) 1 book?? Fixed electrodes #1 (1989); #2 (1989-1990); #3 !990-). Telemetry, insulin hypoglycemia Animal 1571 (3 books, 1988-1996). Ovariectomized 1992. Fixed electrodes #1 (1989); #2 (1990-1991); #3 (1991); #4 (1991-1992); #5 (1992-1993); #6 (1993); #7 (1993), moveable electrodes #8 (1993-1996). Insulin hypoglycemia ? naloxone, practice intrauterine insemination, estradiol capsule trials, euthanasia 1996.
87 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 41 of 80 Animal 1590 (2 books, 1987-1991). Ovariectomized 1988. Fixed electrodes #1 (1987-1989); #2 (1989-1991). Habituation and naltrexone, insulin hypoglycemia, morphine. Animal 1596, (Books 1-4 of 6, 1987-1993). Ovariectomized 1987. Fixed electrodes #1 (1987-1988); #2+ ICV (1988-1993). CRF ? metyrapone, CRF ? naloxone, GnRH, morphine ? naloxone, estradiol ? naloxone, NMDA ? morphine, NMDA ? phenoxybenzamine, telemetry, light/dark ? noise, aCSF, AP5, norvaline, naloxone ? alcohol, progesterone, long acting GnRH, transmitter tests, insulin hypoglycemia ? naloxone ? estradiol, BrainWaves, telemetry, CB154 and pulse generator, EB-induced LH surge, died 1993.
88 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 42 of 80 Animal 1596 (continued, books 5 and 6 of 6). See box 37 for details Animal 1638 (3 books, 1986-1994). Ovariectomized 1992. Fixed electrodes #1 (1987); #2 (1989-1991). #3 (1991-1992). Pituitary push pull cannula (1992). Telemetry, practice intrauterine insemination, NMDA.
89 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 43 of 80 Animal 1639 (1 book, 1985-1988). Ovariectomized 1987. Fixed electrodes #1 (1987-1988). CRF, temperature and MUA volleys. Transferred. Animal 1652 (5 books, 1992-1996). Fixed electrodes #1 (1992-1993); #2 (1993); #3 (1993); moveable electrodes #4 (1994…). CB154, antiestrogen ICI 182780, foster mother attempt, autosampling and foster mothering, euthanasia 1996.
90 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 44 of 80 Animal 1664 (2 books, 1987-1994). Ovariectomized 1990. Fixed electrodes #1 (1987-1988); #2 (1989-1991); #3 (1991….). LH and GH, volleys after ovariectomy, lesioned Animal 1680 (books 1-3 of 6, 1986-1993). Ovariectomized 1987. Fixed electrodes #1 (1986….). CRF ? morphine, CRF ? metyrapone, CRF ? naloxone, naloxone ? morphine, naloxone ? estradiol, NMDA ? morphine, NMDA ? phenoxybenzamine, progesterone, BrainWaves, insulin hypoglycemia ? rCRF 12-40 antagonist, light/dark, GABA, alpha-helical CRF, melatonin, telemetry, MK801, CPP icv, TRH, foster mother in telemetry, CB154, transferred 1993.
91 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 45 of 80 Animal 1680 (books 4-6 of 6). See box 41 for details Animal 1682 (1 book, 1987-1989). Ovariectomized 1988. Fixed electrodes #1 (1988).NMDA ? phenoxybenzamine, estradiol and progesterone effect on pulse generator, 24-hr fast and GH, estradiol ? naloxone Animal 1693 (book 1 of 6, 1992-1997). Ovariectomized 1993. X-rays included. Fixed electrodes #1 (1992). Volleys after ovariectomy, foster mother in telemetry, naltrexone infusion, osmotic minipump, morphine, estradiol/cholesterol capsule, L-arginine, antide, insulin hypoglycemia ? icv infusion of “unknown substance 1693-1″, EGF, leptin, icv oxytocin (last lab experiment 8/25/97).
92 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 46 of 80 Animal 1693 ( Books 2-6 of 6). See box 41 for details
93 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 47 of 80 Animal 1666 (3 books, 1982-1997). Ovariectomized 1993. Fixed electrodes #1 (1992); icv 1995. Clomiphene citrate, icv GnRH, Antide, insulin hypoglycemia ? antiAVP, AVP ? antiAVP, testosterone ? arimidex (aromatase inhibitor). RhEGF, leptin icv, estradiol capsules, EEG, morphine ? leptin, insulin hypoglycemia ? “unknown substance” Animal 1699 (books 1-3 of 7, 1992-1997). Ovariectomized 1993. Fixed electrodes #1 (1992-1997). Volleys after ovariectomy, telemetry and foster mother and lactation, D-arginine, NO, hPRL, antide, GnRH, AVP ? antiAVP, insulin hypoglycemia, testosterone ? arimidex (aromatase inhibitor), leptin, morphine, estradiol capsules, EEG, “consciousness”, insulin hypoglycemia double-blind experiment.
94 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 48 of 80 Animal 1699 (box 4-7 of 7, see box 43 for details). Animal 1702 (book 1 of 7, 1992-1997). Fixed electrodes #1 (1992-1993); #2 (1993); moveable electrodes #3 + icv (1993…). Antiestrogen ICI 182780, telemetry + lactation, foster mother, AVP, EGF, osmotic minipump, antiestrogen + EB experiment (EGF book), CB 154 and lactation
95 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 49 of 80 Animal 1702 (books 2,3,4,5, and 7 of 7) see box 44 for details
96 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 50 of 80 Animal 1702 (book 6 of 7). See box 44 for details Animal 1730 (books 1-4 of 16, 1991-1997) X-rays. Fixed electrodes #1 (1991); #2 (1991-1992); #3 (1992….). Artificial insemination trials, telemetry and lactation and foster mother, TRH EGF/A25, CRF, AVP, ICV 1995.
97 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued) Box 51 of 80 Animal 1730 (books 5-9 of 16) see box 46 for details
98 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 52 of 80 Animal 1730 (books 10-13 of 16) see box 46 for details
99 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 53 of 80 Animal 1730 (books 14-16 of 16) see box 46 for details Animal 1742 (book 1 of 3, 1989-1995). X-rays. Fixed electrodes #1 (1989-1990); #2 (1991); #3 1991-1992); #4 (1992); #5 (1992); #6 (1993); moveable electrodes #7 (1993-1994); #8 (1994….). Antiestrogens, euthanasia 1995.
100 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 54 of 80 Animal 1742 (book 2,3 of 3) see box 49 for details Animal 1794 (2 books, 1988-1989). Fixed electrodes (1988). Naloxone, GnRH, D-Trp, estradiol effect on pulse generator, EB in the follicular phase, LH and GH, died 1989. Animal 1796 (2 books, 1987-1990). Fixed electrodes #1 (1987-1989); #2 (1989-1990); #3 (1990…). Telemetry.
Return to the Table of Contents
101 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 55 of 80 Animal 1803 (4 books, 1991-1996). Fixed electrodes #1 91991); #2 (1991-1992); #3(1992); #4 (1992-1993), #5 (1993); moveable electrodes #6 (1993…). Telemetry and lactation, euthanasia 1996. Animal 1804 (book 1 of 6, 1989-1997). Fixed electrodes #1 (1989-1990), #2 (1990-1993); moveable electrodes #3 (1993-1997). Telemetry cycles, follicular, and luteal and LH surge time courses, progesterone, insulin hypoglycemia ? naloxone, melatonin, light/dark, CB154 and pulse generator, antiestrogen ICI 182780, telemetry with foster mother and lactation trials. ICV 1995. She does not accept foster babies.
102 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 56 of 80 Animal 1804 (books 2-6 of 6). see box 51 for details
103 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 57 of 80 Animal 1801 (5 books, 1991- 1995). Fixed electrodes #1 (1991); #2 (1991-1992); #3(1992-1993); #4 (1993); moveable electrodes #5 (1993-1994). Intrauterine insemination trials, telemetry and lactation, antiestrogen ICI 182780, euthanasia 1995.
104 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 58 of 80 Animal 1815 (2 books, 1992-1997). Ovariectomized 1993. Fixed electrodes #1 (1992-1993). Moveable electrodes #2 (1993-1997). Clomiphene, ICV 1995. Insulin hypoglycemia ? antiAVP, testosterone ? arimidex (aromatase inhibitor), morphine, Animal 1823 (2 books, 1991-1996). Ovariectomized 1992. Fixed electrodes #1 (1991-1992), #2 + icv (1993-1995); moveable electrodes #3 (1995-1996). MK 801 ? NMDA. Vasopressin, insulin hypoglycemia ? antiAVP, aCSF, euthanasia 1996. Animal 1830 (2 books, 1992-1996). Fixed electrodes #1 (1992-1993);, #2 (1993); moveable electrodes #3 + icv (1993-1995); #4 (failed). Antiestrogen ICI 182780, euthanasia 1996.
105 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 59 of 80 Animal 1835 (4 books, 1989-1997). Ovariectomized 1990. Fixed electrodes #1 (1989-1995; moveable electrodes + icv (1995…). Volley duration after ovariectomy, insulin hypoglycemia ? estradiol, insulin hypoglycemia ? alpha-helical CRF, insulin hypoglycemia ? anti rCRF, insulin hypoglycemia ? dexamethasone, light/dark telemetry, NMDA, TRH, AVP ? antiAVP, aCSF, anti-GnRH. Animal 1864 (1 book, 1993-1997). Fixed electrodes #1 (1993…;) AVP icv
106 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 60 of 80 Animal 1868 (1 book, 1989-1990). Fixed electrodes #1 (1989), #2 (1990). EB treatment, insulin hypoglycemia. Animal 1871 ( books 1-4 of 6, 1990-1996). Ovariectomized 1992. Icv 1993. Fixed electrodes #1 (1990-1991); #2 (1992); #3 (1992…). Insulin hypoglycemia ? naloxone, telemetry, insemination, CB154, AVP ? antiAVP, Prl and LH, insulin hypoglycemia ? antiAVP, L-NMMA ? antiAVP, D-NMMA, insulin hypoglycemia ? CRF analog, antiestrogen (ICI), icv volume tests, hPRL, antide, aCSF, NPY-Y analog (PXY-2),, euthanasia 1996.
107 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 61 of 80 Animal 1871 (books 5,6 of 6). See Box 56 for details. Animal 1913 (2 books, 1989-1991). Fixed electrodes #1 (1989=1990); telemetry, died 1991. Animal 1930 (Book 1 of 2, 1989-1991). Ovariectomized 1990. Fixed electrodes #1(1989-1990); icv, estradiol, melatonin, insulin hypoglycemia ? naloxone, insulin hypoglycemia ?CRF antagonist, telemetry,,light/dark, MK801, CPP(NMDA antagonist), died 1991.
108 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 62 of 80 Animal 1930 (book 2 of 2). See box 57 for details. Animal 1931 (books 1-4 of 6, 1995-1997). Moveable electrodes + icv (1995-1997). Telemetry, foster mother and lactation
109 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 63 of 80 Animal 1930 (books 5,6 of 6). See box 58 for details Animal 1961 (3 books, 1993-1007). Moveable electrodes #1 (10093-1997). Telemetry, lactation and foster mother, icv.
110 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 64 of 80 Animal 1999 (2 books, 1992-1993). Ovariectomized 1993. Fixed electrodes #1+ icv (1993-). Clomiphene, telemetry, lactation and foster mother.. Animal 2034 (4 books, 1990-1996). Ovariectomized 1992.Fixed electrodes #1 (1991); #2 1991-1992);, #3+icv (1992-1995), moveable electrodes #4 (1995-1996). Cervical dilation, telemetry, AVP, insulin hypoglycemia ? antiAVP, insulin hypoglycemia ? antiCRF, lactation and foster mother, L-NMMA, osmolarity test, aCSF, euthanasia 1996.
111 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 65 of 80 01: 1 book, 1994, moveable electrodes +icv #1 (5-26-94). #2 (10-31-95). No MUA 03, 1 book, 1994, moveable electrodes+icv #1, 1994. No MUA, l-arginine. Died 3-23-95 04, 1 book, 1994, moveable electrodes+icv #1 (10-31-94). No MUA. Euthanasia 2-19-96 05, 1 book, 1994-96, moveable electrodes+icv #1 (9-13-94). No MUA. Euthanasia 2-28- 96 06, 1 book 1994-96, moveable electrodes+icv #1(9-7-94). No MUA. Euthanasia 2-21-96 07, 1 book 1994-96, moveable electrodes #1 (8-8-94), ovariectomized 10-15-96. No MUA.
112 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 66 of 80 08, 1 book 1994-96, moveable electrodes+icv #1 (8-11-94). No MUA. Euthanasia 3-1-96 09, 1 book 1994-96, moveable electrodes+icv #1 (10-25-94). No MUA, luteal l-arginine Euthanasia 2-7-96 119, 1 book 1995-96, moveable electrodes #1 (10-5-95). No MUA 239, 1 book 1995-96, moveable electrodes #1 (9-5-95). No MUA 337, 1 book 1995-96, moveable electrodes #1 (10-12-95). No MUA. Euthanasia 4-29-97 355, 1 book 1995-96, moveable electrodes #1(9-26-95). No MUA 357, 1 book 1995-96, moveable electrodes #1 (9-21-95). No MUA
113 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 67 of 80 367, 1 book 1995-97, moveable electrodes #1 (9-25-95). No MUA. Euthanasia. 4-7-97 827C, 1 book 1995-97, moveable electrodes #1 (10-24-95). No MUA. Euthanasia 1-30-97 829C, 1 book 1995-97, moveable electrodes #1(10-3-95). No MUA. Euthanasia 2-4-97 1509, 2 books 1987-92, fixed electrodes #1 (10-29-87 to 11-29-89), #2 ( 1-11-90 to 7-29-91), #3 (1-14-92 to 4-30-92). No MUA 1446, 2 books, 1985-1995, ovariectomy 1/10/91, Fixed electrodes #1 (12-23-86. ), #2 (4-10-89 to 2-13-90), #3 (2-22-90 to 6-20-91), #4 moveable electrodes (10-28-93 to 6-22-95 euthanasia). No MUA
114 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 68 of 80 1454, 2 books, 1987-1995. Ovariectomy 7-28-92. Fixed electrodes #1 (12-8-87 to 2-20-D90), #2 (3-15-90 to 3-21-90), #3 (3-22-90 to 5-1-91), #4 (6-4-91 to 7-20-92) #5, 4-8-93…). 1422, 1 book, 1989. Died during electrode implantation, 1989 1429, 1 book, 1982-1984. Ovariectomy 1982. Fixed electrodes #1 (4-14-83 to 11-11-83). #2 (1-11-84…) Estradiol capsules and naloxone. No MUA. 1430, 1 book, 1983-1984. Ovariectomy 1983. Fixed electrodes #1 (12-6083 to 2-6-84), #2 (2-15-84…) Euthanasia 4-5-84. 1434, 1 book (1982-1983). Ovariectomy 1982.Fixed electrodes #1 (8-25-83), Died 12-17-83. No MUA 1438, 1 book, 1982-1983. Ovariectomy 1982. Fixed electrodes #1 (11-17-82). Euthanasia 3-17-83 1440, 1 book, 1982-1983. Ovariectomy 1982. Fixed electrodes #1 (3-10-83 to -11-83), died 7-13-83
115 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 69 of 80 1454, 2 books, 1987-1995. Ovariectomy 7-28-92. Fixed electrodes #1 (12-8-87 to 2-20-90), #2 (3-15-90 to 3-21-90), #3 (3-22-90 to 5-1-91), #4 (6-4-91 to 7-20-92) #5, 4-8-93…). 1422, 1 book, 1989. Died during electrode implantation, 1989 1429, 1 book, 1982-1984. Ovariectomy 1982. Fixed electrodes #1 (4-14-83 to 11-11-83). #2 (1-11-84…) Estradiol capsules and naloxone. No MUA. Ovariectomy 1983. Fixed electrodes #1 (12-6083 to 2-6-84), #2 (2-15-84…) Euthanasia 4-5-84. 1434, 1 book (1982-1983). Ovariectomy 1982.Fixed electrodes #1 (8-25-83), Died 12-17- 83. No MUA 1438, 1 book, 1982-1983. Ovariectomy 1982. Fixed electrodes #1 (11-17-82). Euthanasia 3-17-83 1440, 1 book, 1982-1983. Ovariectomy 1982. Fixed electrodes #1 (3-10-83 to -11-83), died 7-13-83
116 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 70 of 80 1178, 1983-1985, ovariectomized 1-3-83. Fixed electrodes #1 (7-26-83 to 2-9-84). #2 (2-22-84 to 10-25-84). Stress+naloxone, phenoxybenzamine time course, sold 1985. 2 books 1189, 1982-1984. Ovariectomized 11-29-83. Fixed electrodes 5-8-84…loose, sacrificed 6- 6-84. M-2, MALE, collection of serum for RIA (same book as 1189). 1210, 1987-1991. Ovariectomized 7-28-88. Fixed electrodes #1 (3-1-88 to 1-17-89). #2, (3-9-89 to 12-21-90). #3, (6-27-91 …). Died 7-24-91 1217, 1989-1990. Fixed electrodes + icv (11-16-89 to 9-19-90) 1223, 1982-1984. Ovariectomized 12-3-81. Recording well implantation (5-14-82 (Pittsburgh) -5-20-83). 1247, 1983-1984. Ovariectomized 10-4-83. Fixed electrodes (1-31-84). 1251, 1982-1987. Ovariectomized 2-11-82. Recording well implantation (11-15-82 to 7-19-83). Fixed electrodes #1 (8-11-83 TO 10-25-84), #2, (9-3-85…)
117 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 71 of 80 1251, Book 2 1256, 1982. Died of endocarditis, no electrodes. 1262, 1991-1994. Ovariectomized 10-30-91. Fixed electrodes (4-25-91-10-04-93) H by RIA and bioassay. Transferred to Fellerman. 1263, 1985-1986. Ovariectomized 1985, Fixed electrodes (9-5-85 to 6-6-86). Transferred 6-18-86. 1270, 1982-1983. Ovariectomized 1982. Fixed electrodes 2-3-83. Died. Clonidine time course. 1274, 1983-1984. Ovariectomized, no electrodes 1277, 1983-1985. Ovariectomized 6-12-84. Fixed electrodes #1 (9-2-83 to …), #2 (11-19- 84 to 3-20-850. Sold to Goossy. 1285, 1982-1983. Ovariectomized 1982. Fixed electrodes 3-8-83. Sacrificed, lesioned and perfused 7-21-83. 1300, MALE, 1991, electroejaculation trials. Found not suitable, very little data 1312, returned to Pittsburgh 2-26-91. No electrodes,
118 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 72 of 80 1318, 1983-1984. Ovariectomized 1983. Fixed electrodes 7-7-83. 1326, 1982-1983, Ovariectomized 1981. Fixed electrodes (2-8-83 to 6-16-83). Given to Garcia. 1354, 1981-1983. Ovariectomized 1981. Recording well (11-10-82 to 7-19-83). Fixed electrodes (8-9-83), died. 1437, 1983, died, continued book is book 1 of 1362. 1362 1983-1985?. Ovariectomized 1983. Fixed electrodes #1 (4-16-84 to 6-28-84), #2, (11-13-84…..) Not very good MUA 1364, Ovariectomized 983, no other data 1370, 1985, no data ? 1371, 1983 Ovariectomized, no electrodes, no data 1372, Ovariectomized 198112, no electrodes, sold.
119 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 73 of 80 1374, 1983-1984. Ovariectomized 19182. Fixed electrodes 8-4-83. 1379, 1982-1983. Ovariectomized 1981, electrodes 3-22-83, died 1384, 1984-1985. Ovariectomized but still cycles! 1388, 1983-1984, ovariectomized 11-22-83. Electrodes 3-30-84. Sold. 1390, 1983-1984. Ovariectomized ? 1-6-84, electrodes (1-25-84 to 3-16-84) Gave to Crawford. 1395, 1993. Ovariectomized 1-4-93, electrodes (82-283…). Sacrificed 11-4-83. 1460, 1990. Electrodes (7-31-90..), removed from colony 1465, 1988. Electrodes 3-7-88. Died 3-13-88. 1470, (1990-1991. No electrodes, not used, returned to Pittsburgh. 1518, 1992, Electrodes aborted, died
120 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 74 of 80 1473, 1986. Electrodes #1 (10-2-86 to 12-15-87); #2, (aborted). Quercitin 1527, 1987–1989. Ovariectomized 3-29-88. Electrodes #1 (10-22-87 to 8-17-88), #2 10- 26-88 to 9-19-89), #3 5-18-89 to —) LH, GH 1532, 1992-1996. Electrodes #1 (12-10-92 to 6-3-93), #2, Moveables 8-19-93 to 3-15- 94), #3, moveables, 9-27-94 to 5-4-95). Lactation foster attempt, gave to Crawford 2/15/96. 1537, 1987-1989. Electrodes #1 (6-8-89..) Died 9/12/89. 1593, 1984-1985. Ovariectomized 12-3-84. Electrodes #1 (7-10-85..) Died 1599, 1989-1990. Ovariectomized 1983. Electrodes #1 8-2-90 to 10-8-90). 1600, 1988-1989, Ovariectomized 19183. Sick a lot, sacrificed 1-25-89.
121 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 75 of 80 1651, 1990. Blind, electrodes #1 (-16-90 to 10-8-90) 1669, 1991-1993. Electrodes #1 5-2-91. Euthanasia 1-29-93. 1670, 1987-1989. Electrodes #1 (9-1-87 to 10-25-88_, #2, 3-29-89…) Out of colony 1-14- 89. 1679, 1986. Electrodes 2-13-86. Died 7-7-86. 1698, 1990-1991. No electrodes, sent back to Pittsburgh. 1734, 1989-1993. Ovariectomized 1986. Electrodes #1 (6-5-91 to 3-16-93), transferred to Fellerman 12-22-93. 1745, 1989-1991, ovariectomized 10-10-86. Electrodes #1 (7-19-90 to 8-29-90); #2, 7- 18-91 to 10-16-91. Given to Marshak 11-19-91
122 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 76 of 80 1782, 1988-1995 (2 books). Ovariectomized 6-13-89.Electrodes #1 (2-23-88 to 8-15-90), #2 (7-11-90 to 5-12-93), #3, (6-24-93 to 11-5-93), #4 moveables (2-24-94…) Euthanasia 6-8-95. 1798, 1994-1997. Moveable electrodes #1 (5-12-94 to 10-18-95), #2, 12-7-95…). ZM 182,780. 1810, 1994-1995. T4 measured. Thyroidectomy. Moveable electrodes #1 (4-13-94…) 1836, 1987-1991. Electrodes #1 (8-10-89..). Anomalous anatomy 1872, 1990-1991. No electrodes, no data except anovulatory menstrual cycles. 1902, 1993-1994. Electrodes #1 (7-8-93-1-5-94); #2 moveables (3-3-94-5-6-94); #3 moveables (9-1-94…), died 9-3-94
123 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 77 of 80 2043, 1993-1995. Moveable electrodes #1 (10-7-93..). Euthanasia 8-23-95. 2066, 1994-1995. Moveable electrodes #1 + ICV (11-3-94..) L-arginine. Euthanasia 9-1-95. 2154, 1995-1997. Moveable electrodes #1 + ICV (7-20-95…) 2191(Male), 1991, electroejaculation and semen analysis,
124 Hypothalamic Regulation of Reproductive Function:
124-A C. Electrical recording in the mediobasal hypothalamus (continued): Box 78 of 80 Headcap Log Books (I and II), Telemetry development books (I And II), Transmitter log books (I and II), HARDWARE: electrodes, icv cannula, box of probe testing gadgets, electrode parts, augat connectors, moveable electrodes from animal 1066, and other used headcaps”, halos and housings for headcaps.
125 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 79 of 80 Transmitters, probes, Probe notebook, Monkey skull with prototype electrode assembly, pituitary portal sampling set-up.
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126 Hypothalamic Regulation of Reproductive Function:
C. Electrical recording in the mediobasal hypothalamus (continued): Box 80 of 80 Lab meeting minutes and protocols, Houston. 1982-1996
127 Hypothalamic Regulation of Reproductive Function:
D: Pituitary and hypothalamic perfusions, and miscellaneous studies (1970-1994) Box 1 of 2 Department of Physiology, University of Pittsburgh School of Medicine Laboratory for Neuroendocrinology, University of Texas – Houston Medical School Collaborators and fellows: D.L. Hess, T. Ordog, M. Nishiohara, K.T. O’Byrne, J. Hotchkiss, and others. Brain cannulation and “Push-Pull studies. Books 401-408 + 2 Houston books. Book 401 1970-1972. Cannulation of the third ventricle and the infusion of dopamine, norepinephrine, epinephrine, and serotonin icv. Infusion of phenoxybenzamine into the preoptic and arcuate areas. Book 402: 1972-1973. See book 401, Push-pull cannula assessment Book 403, 1973-1974. Push-Pull Cannula book I, Push-pull in the pituitary and arcuate regions Book 404, 1974…Push-Pull Cannula book II. MBH, pituitary. Summary of I and II p. 152 Book 405, 1974-1975. Push-Pull Cannula book III. Pituitary perfusion (acute and chronic preparations, washout studies with 24Na. Book 406, 1975. Push-Pull Cannula book IV, 1975. Pituitary, effects of estradiol.
128 Hypothalamic Regulation of Reproductive Function:
D: Pituitary and hypothalamic perfusions, and miscellaneous studies (continued): Box 2 of 2 Book 407, Pituitary Sampling book I, 1975-1976. Book 408, Pituitary Sampling Book II, 1976-1977. Continuation of pituitary push-pull perfusions in Houston Summary Book I, 1991-1992 Summary Book II, 1992- Anterior Pituitary Organs and Cell Culture, Book I, 1978-1979 and Book II 1979. Pituitary Cell culture , 1979-1980. Role of endogenous opioids in hypothalamic amenorrhea, 1981-1982. Relaxin, (Gerson Weiss) book 609, 1979.
129 Hypothalamic Regulation of Reproductive Function:
E. Postpartum lactational amenorrhea (1972-1997) Box 1 of 4 Depatrtment of Physiology, Univeristy of PittsburghSchool of Medicine E. Schallenberger, T.M. Plant, D.L. Richardson, A. Hausler, C.R. Pohl, L. Wildt, G. Weiss Laboratoary for Neuroendocrinology, University of Texas – Houston Medical School K.T. O’Byrne, T. Ordog, J. Goldsmith, M.A. Connaughton, J. Hotchkiss, M.-D. Chen, Data in ovariectomized foster mothers, 1979. Hormonal patterns in postpartum animals; in suckled mothers, weaned mothers, TRH-treated weaned mothers, in CB154-treated mothers. Periparturition data: estradiol, estrone, progesterone Prolactin Series (labeled #251-#253). Prolactin and lactation, Book 1 (#251). (1972-1973). Effects of repeated TRF on prolactin secretion in postpartum lactators. Prolactin Book 2 (#252). 1973-1974. Effect of ovine prolactin on the luteal phase. Progesterone clearance during lactation. Prolactin secretion patterns during the puerperium. Thyroidectomy. Induction of ovine Prl antibodies and treatment with rhPrl. Effect of ovine Prl on the hCG-recused CL. Effect of suckling on tonic LH secretion in postpartum lactators. Attempt to induce lactation with ovine Prl in animals suppressed with CB154. Preparation of Prl-free serum. Attempts to induce lactation in hypophysectomized animals. Do lactating animals show a diurnal rhythm in cortisol? Testing for lactation in non-pregnant animals. Prolactin Book 3 (#253). 1980. Prolactin as a luteotropic hormone. Special surgery book, 1971. (#601). Pituitary transplantation. Book: Progesterone clearance studies in the luteal phase and during lactation. 1973. Studies of the disappearance rate of estradiol in prepubertal and adult female monkeys 1978.
130 Hypothalamic Regulation of Reproductive Function:
E. Postpartum lactational amenorrhea (continued): Box 2 of 4 (PPLA series, labeled # 201 to 208, Pittsburgh). Book 1 (#201), 1964-1975. Effect of rhPrl on postpartum corpus luteum function. CB154 protocol for suppression of endogenous Prl, periparturitional data, foster mothers Book 2 (#202), 1975-1976. Suckling and postpartum amenorrhea (There is no book 3 (#203). Book 4 (#204). Behavioral monitoring during postpartum lactational amenorrhea. Book 5 (#205) Effect of artificial suckling on prolactin secretion, 1975-1978. Determination of LHRH in milk and plasma samples from lactating monkey and in plasma of pregnant monkey. Book 6 (#206), Prolactin during suckling, 1978-1979. CB154 and osmotic minipumps, Book 7 (#207). 1978. Continued. EB challenges during suckling. Book 8 (#208). 1979. Continued. Foster mothers, weaning and puerperal corpus luteum rescue study
131 Hypothalamic Regulation of Reproductive Function:
E. Postpartum lactational amenorrhea (continued): Box 3 of 4 Book 1: 1992-1993. Lactation induction with TRH, Animals 1269, 1680, 1058, 1343, 1730, 1699, Dose determination for CB154 Book 2: 1993-1994. Lactation, continued. Effect of CB 154 on volley frequency. Animals 1999, 1693, 1497, 1523, 1961, 1804, 1792, 1523, 1803, 1652, scoring milk production. Book 3: Lactation, continued. 1994-1995. Animals 1730, 1702, 1343 Book 4, Lactation, continued. 1996-1997. Animal 1931. Monitoring Suckling Behavior, Books 1 and 2 of 5, 1994-1995.
132 Hypothalamic Regulation of Reproductive Function:
E. Postpartum lactational amenorrhea continued): Box 4 of 4 Monitoring Suckling Behavior, Books 3-5 of 5. Foster mother bleed sheets, weights of infants (1975-77), ovariectomized foster mother data
133 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (1982-1997): Box 1 of 14 Laboratory for Neuroendocrinology, University of Texas – Houston Medical School Collaborators and fellows: R.C. Wilson, D. Ladendorf, C. Williamson, J. Goldsmith, H. Cardenas, T. Ordog, K.T. O’Byrne, J.C. Kesner, M. Nishihara, and others, Houston: Experiment Index, July 1982-1986. Protocol Book, July 1982-November 1985 Habituation Log Book, 1988-1995 Looseleaf Folder: Assay Status and Sample Records, 1991-1997
134 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 2 of 14 Methods and Procedures I: 1982-1990. Headcap making, electrode placements, stereotaxic zero procedure, how to sterilize electrodes, calculation of electrode coordinates, surgical packs, estradiol implants (preparation, incubation, placement and removal, best method of preparation of blood samples, streptokinase notes, flow rate calibration of Gilson pumps, procedures from drawing blood through cardiac catheters, Dataquest operating instructions, preparation of estradiol benzoate and progesterone solutions, specifications for X-ray films and exposures, electrode manufacturing procedures (updated), schematic diagram of hard wiring system, frequency bandwidth for recording neural activity Methods and procedures II, 1990-1995. Volley success rate, 1985-1989; method for preparing blood collecting assembly, coordinates of ICV cannula, head cap inspection procedure, vancomycin, calibration of Harvard pump, how to dissolve ?-helical CRF 9-41 (CRF antagonist) and other material in water for injection, calibration of pumps for push-pull perfusion, electrode assembly update, electrode plays poker(A-P) from 1985-1991, success rates in monkeys 1981-1993; exothermy and the dental acrylic; testing frequency bandwidth, preparation of TRH, preparation of Primilac(monkey infant formula); preparation of moveable electrode assembly (Charles Williamson); platinum blacking of electrodes, changes to electrode fabrication and implantation procedures (March 1994); rules for calculating MUA frequency, rules for assembling the automated blood sampling apparatus, new design of ICV cannulae, Assembly and calibration of Moveable electrode assemblies Type III (1995). Estimation of MUA volley frequency, 1994—, Recording electrodes, 1991-1992. Bacteriological culture reports book, 1991-1992.
135 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 3 of 14 Studies: Book: Glucose measurements (1990), First light/dark studies and the role of melatonin, (1991); Latex agglutination assay for monkey pituitary hormones, RhGH (1991); Book: Pregnancy 1991: electroejaculation (1991-1992); intrauterine insemination attempts Book: ICV LHRH (1987-1988); Long acting GnRH (1988); Light/Dark I (1987-… Book: Light/Dark II, (1991-1992). Book: Naloxone ? pentothal in intact females (1987-1988); Naloxone ? ethanol in ovariectomized monkeys.. Book: Volley duration after ovariectomy, (1988–). Book: Summary of electrodes recordings, (1983-1985) Book: Naltrexone and the LH surge, (1993).
136 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 4 of 14 Book: Insulin hypoglycemia (1990-1992). Book: Insulin hypoglycemia and naloxone (1990-1993). Book: ICV prolactin and its effect of the pulse generator ( 1994). Book: Intact screens, (1987-1990); Clomiphene citrate protocol (1993),. Book: Area under the curve (LH) vs volley duration 91988); Unusual effects of naloxone and alcohol on increasing the frequency of the pulse generator Book: NMDA and GnRH pulse generator activity (198801991) using MK801, CPP, and aCSF; Nitric oxide studies (1993-1995) using L-NMMA, D-NMMA, volume experiments with aCSF, high osmolarity experiments, L-arginine
137 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 5 of 14 Book: Progesterone studies (1989-1994); Book: CRF and morphine (1987-1989), and ICV CRF, (1995-1996) Books: (n=2) Telemetry during the menstrual cycle (1988-1990) and (1990…) Book: Estradiol experiments, effects of the pulse generator with EB..does it mimic the surge? (1989–). Book: AntiGnRH experiments: Is GnRH a neurotransmitter to the pulse generator? (1994-1995). ICV GnRH antagonist Book: NPY as a neurotransmitter (1995-1996). Book: Leptin, 1996-1997. Book: Effect of testosterone ? aromatase inhibitor (Arimidex) on pulse generator frequency, 1996
137A Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 6 of 14 Book: AVP-anti-AVP, protocols and data summary Book: Physical signs and observations during insulin-induced hypoglycemia, protocol and data, role of AVP Book: Antiestrogen studies: ICI 182,780 Books(2):Type II estradiol binding suites and the surge, EGF and the neuroendocrine effects of estradiol
138 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 7 of 14 Radioimmunoassay and bioassay development Protein Hormone Radioimmunoassay Books, Houston Reagents and iodinations, etc., 1982-1989, LH, FSH, GH, etc., Gonadotropin assays + EGF RIA, 1989-1996 125I RIA book Protein Hormone RIA’s Quality control, 1981-1989. LH RIA book, 1987 — GnRH RIA, 1991-1997 (2 books)
139 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 8 of 14 Radioimmunoassay and bioassay development LH Bioassay books 1-7 (see also “H series ” books for B0001-B0083) Cortisol assay book, 1991– (see also “H series” books for prior to 1991) Cortisol assay book, from Pittsburgh, 1973
140 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 9 of 14 Radioimmunoassay and bioassay development Progesterone Assay Log books (n=3), Houston, (See also “H series” books for prior to 1991. Prolactin Assay Log books (n=2), Houston, 1=1986-1993, 2=1993-1997. See also Protein Hormone RIA book for prior data Growth Hormone RIA books (n=2), Houston, 1=1987-1991, 2=data summary re relations between MUA frequency and GH pulses in the serum.
141 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 10 of 14 Radioimmunoassay and bioassay development “H series” Books (n=14). These contain steroid radioimmunoassays (estradiol, cortisol, progesterone, testosterone, and other nonsteroid RIA’s ). Book 1, 1982-1983; Book 2 , 1983-1984, containing the first LH bioassays B0001-7; Book 3, 1984-1985
142 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 11 of 14 Radioimmunoassay and bioassay development “H series” books, continued. Book 4, 1985 + B0010-16; Book 5, 1985-1986, B0017-24; Book 6, 1986, B0025-29
143 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 12 of 14 Radioimmunoassay and bioassay development “H series” books, continued. Book 7 , 1986-1987, B0030-47, Book 8, 1987, B0048-78
144 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 13 of 14 Radioimmunoassay and bioassay development “H series” books, continued. Book 9, 1987-1988, B0083. Book 10, 988-1989; Book 11, 1989-1990; Book 12, 1990.
145 Hypothalamic Regulation of Reproductive Function:
F. Methods, studies, protocols, technical developments (continued): Box 14 of 14 Radioimmunoassay and bioassay development “H series” books, continued. Book 13, 1991; Book 14, from 1991. After this, each steroid assay has its own set of notebooks. This is a development and testing book. FSH Books 1 and 2; 1987-1994. FSH RIA development
146 Hypothalamic Regulation of Reproductive Function:
G: Brain Waves Analyses (1989-1997) Box 1 o f 2 Laboratory for Neuroendocrinology, University of Texas – Houston Medical School Collaborators and fellows: H. Cardenas, T Ordog, J.C. Thalabard, K.T. O’Byrne, BrainWaves books: 1-10 of 13 Book 1: September 1989-December 1990. Book 2: 1990-1991. Animal 1269 Book 3: 1989- Protocol. 1680 Book 4: 1990-1991. Animal 1596 Book 5: 1990-1991. Animal 1269 Book 6: Animal 1269 Book 7: 1991. Animal 1343. Book 8: 1991, Animal 1804 Book 9: 1991, Animal 2034 Book 10: 1991, Animal 1496
147 Hypothalamic Regulation of Reproductive Function:
G: Brain Waves Analyses (continued) Box 2 of 2 Books 11-13 of 13. Book 11: 1991, Animal 1680. Book 12, index of sorts Book 13: 1990, Animal 1546 space for more books more books to come
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