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Showing 1 to 21 of 21 items tagged as proteins


SpringerProtocols

database

Provider: Springer Science & Business Media LLC
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Descriptions: SpringerProtocols is said to be the most comprehensive and trustworthy online database of reproducible laboratory protocols in the biomedical and life sciences. From the book series Methods in Molecular Biology and numerous other sources, this collection offers researchers access to decades of step-by-step protocols for use in the lab. With an emphasis on clarity, each protocol is organized in an easily-reproduced, recipe style. All protocols have been written by experts in the field, and are reviewed first by editors distinguished in the relevant specific subject areas, and then by Springer's own editorial staff. Contains some open-access protocols. Mobile version of website available.
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Structure (NCBI)

database

Provider: National Center for Biotechnology Information (NCBI)
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Descriptions: The NCBI Structure Group, a part of the Computational Biology Branch of NCBI, developed this suite of four free molecular and protein databases, each of which is itself made up of several others, and all of which can be searched individually. Macromolecular Structures, Conserved Domains, Small Molecules, and Biological Systems are the four main resources here- tools designed to facilitate discovery of sequence, function and structure associations. The tab labeled "Discover" does a good job of explaining how to use the Structure databases and how to access various facets of information on a molecule or protein from any point in NCBI's many resources.
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STAR (Software Tools for Academics and Researchers)

database

Provider: MIT (Massachusetts Institute of Technology)
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Descriptions: The STAR program team designs software exploring core scientific research concepts, innovative and intuitive teaching tools for classroom use, helping to close the gap between scientific research and the classroom. So far, STAR units include: STARBiochem, a protein visualization tool (structural biology); STARBiogene, a set of genomic visual and analytic tools; STARGenetics (analysis of genetic traits); STARHydro (hydrology visualization); STARMolSim (molecular dynamics simulations); and STARHPC (parallel programming education.)
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Structural Biology Knowledgebase

database

Provider: Nature.com and PSI (Protein Structure Initiative)
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Descriptions: The Structural Biology Knowledgebase (SBKB) is the product of a collaboration between the Protein Structure Initiative (PSI) and Nature Publishing Group (NPG.) The site offers an easy way of keeping up to date on the latest developments from the PSI, and more generally, in the fields of structural genomics and structural biology. Some areas of this site require a free registration involving affirmation of a statement declaring that one's purpose is strictly non-commercial and that one is an academic.
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Protein Data Bank: An Information Portal to Biological Macromolecular Structures

database

Provider: RCSB (Research Collaboratory for Structural Bioinformatics)
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Descriptions:  "The RCSB (Research Collaboratory for Structural Bioinformatics) is dedicated to improving our understanding of the function of biological systems through the study of the 3-D structure of biological macromolecules. RCSB members work cooperatively and equally through joint grants and subsequently provide free public resources and publications to assist others and further the fields of bioinformatics and biology."  Protein Data Bank (PDB) curates and annotates data according to agreed-upon standards and is a member of the ww (world wide) PDB. Use this database to perform simple and advanced searches based on sequence, structure and function annotations, and to visualize, download, and analyze molecules. The database is primarily for researchers, but the site also includes an entire section (PDB101) of information quite accessible enough for educational purposes. Check out the "Molecule of the Month" feature. The extensive archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies.  As with many scientific databases, a personal log-in affords access to more features. The database is managed by Rutgers and University of California San Diego.
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PubChem

database

Provider: National Center for Biotechnology Information/National Library of Medicine
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Descriptions: PubChem provides information on the biological activities of small molecules and is a component of NIH's Molecular Libraries Roadmap Initiative. It includes substance information, compound structures, and bioactivity data in three primary databases: PCSubstance, PCCompound and PCBioAssay. PCSubstance contains more than 12 million records; PCCompound contains more than 7 million unique structures; and PCBioAssay contains more than 200 bioassays.
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UniProt

database

Provider: UniProt Consortium
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Descriptions: "The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information."  Available material consists of: UniProtKB, a two-section protein knowledge-base consisting of SwissProt and TrEMBL; UniRef (sequence clusters;) UniParc (a sequence archive for tracking sequences and identifiers) and the supporting data (literature citations, taxonomy, keywords, nomenclature, guidelines and indexes.) A user manual and primer on annotation are provided as well. UniProt is distributed free under a Creative Commons attribution license. Updates are frequent and updated releases must be downloaded from the website. Much of UniProt's funding is provided by the NIH.
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Proteopedia: Life in 3-D

database

Provider: Weizmann Institute of Science
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Descriptions: Proteopedia is a free, collaborative (wiki) 3-D encyclopedia of proteins and other molecules. The images can be reduced and restored by component with a toggle, or caused to rotate from any starting angle. Contains an introduction to structural biology and features sections on biomolecules, enzymes, metabolism, gene expression/replication, diseases, immune system, and methods of determining and analyzing structure and sequence. Contains a table of contents and a detailed structure index
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NDB: Nucleic Acid Database

database

Provider: The Nucleic Acids Database Research Project/Rutgers University
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Descriptions: A portal for 3-D structural information about nucleic acids, the NDB contains information about experimentally-determined nucleic acids and complex assemblies. Search by annotations relating to sequence, structure and function; download, analyze, and learn about nucleic acids.
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NCBI (National Center for Biotechnology Information)

database

Provider: National Center for Biotechnology Information/National Library of Medicine
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Descriptions: The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. NCBI provides a large number of resources for scientific research, including software and many databases.
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STITCH (Search Tool for Interactions of Chemicals) 3.1: Chemical-Protein Interactions

website

Provider: University of Copenhagen, European Molecular Biology Laboratory, Swiss Institute of Bioinformatics, Technische Universitat Dresden, Universitat Zurich
Descriptions: STITCH is a resource to explore known and predicted interactions of chemicals and proteins. Chemicals are linked to other chemicals and proteins by evidence derived from experiments, databases and the literature. STITCH contains interactions for over 74,000 small molecules and over 2.5 million proteins in 630 organisms." Search by single or multiple: name, chemical structure, or protein sequence; qualify by organism.
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KEGG (Kyoto Encyclopedia of Genes and Genomics)

database

Provider: Kanehisa Laboratories, Japan
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Descriptions: KEGG is a resource purposed to facilitate understanding of the functions and utilities of the biological system--  cells, organisms and ultimately the ecosystem--  based on genomic and molecular-level information. It is a computer representation of the biological system, consisting of the molecular building blocks-- genes, proteins and chemical substances, integrated with molecular wiring diagrams of interaction, reaction and relational networks. Extensive data is available to view; ftp downloading requires a subscription. KEGG was developed in collaboration with the Bioinformatics Center, Institute for Chemical Research, Kyoto University and the Human Genome Center, Institute of Medical Science, University of Tokyo.
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GoPubMed

database

Provider: Transinsight
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Descriptions: GoPubMed is an innovative, powerful search tool that combines the MeSH (Medical Subject Headings) and GO (Gene Ontology) terminologies to optimize the effectiveness of queries to PubMed- for everyone, but for molecular biologists in particular. Searching elicits results presented very quickly (maximum display: the most recent 1,000 citations), along with a sidebar presenting the full results in categorized, hierarchical groups of terms that help the user to focus in further- the producers of this search engine refer to it as a "knowledge-based semantic search." There are many more features to this search tool than can be described here.
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GQuery: Global Cross-database NCBI Search

database

Provider: National Center for Bioinformatics Information (NCBI)
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Descriptions: Integrated, text-based search and retrieval system used at the National Center for Biotechnology Information for its major databases: PubMed, Nucleotide and Protein Sequences, Protein Structures, Complete Genomes, Taxonomy, and others. GQuery integrates the scientific literature, DNA and protein sequence databases, 3D protein structure and protein domain data, population study datasets, expression data, assemblies of complete genomes, and taxonomic information into a tightly interlinked system.
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Center for Biological Sequence Analysis

database

Provider: Technical University of Denmark
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Descriptions: The Center does basic research in the fields of bioinformatics and systems biology. A multidisciplinary group of scientists works in ten specialist research areas (see the CBS Map) and is one of the largest such groups in European academia. Datasets, software, a publications list, and hundreds of links to other related data repositories are included here. Also includes a set of links to courses and lectures.
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BLAST (NCBI)

database

Provider: National Center for Biotechnology Information
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Descriptions: The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches. BLAST can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families.
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BioMart Bio Portal

database

Provider: BioMart
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Descriptions: The BioMart project provides free software and data services to the international scientific community in order to foster scientific collaboration and facilitate the scientific discovery process. The project adheres to the open source philosophy of promoting collaboration and code reuse. The majority of the contributed databases are of plant or human genomics-oriented data. Under Community, view the linked database list with descriptions and contributor names. Databases originate from the UK, USA, France, Spain, China and other countries. There are three separate portal websites-- the central "Bio" portal, a cancer portal, and one for mouse data.  Unfortunately, no link back to BioMart is provided once the user accesses one of the other portals.
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DrugBank: Open Data Drug & Drug Target Database

database

Provider: David Wishart/University of Alberta, CA
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Descriptions: A bio- and chemical informatics resource that combines detailed drug (chemical, pharmacological and pharmaceutical) data with comprehensive drug targeting (sequence, structure, and pathway) information. The database contains nearly 4300 drug entries, including FDA-approved small molecule drugs, FDA-approved biotech (protein/peptide) drugs, "nutraceuticals" and experimental drugs. Contains more than 6,800 drug entries with almost 4,300 non-redundant protein sequences linked. Each entry, or  DrugCard, contains more than 80 data fields, half of which are devoted to drug/chemical data and the other half to drug target/protein data. Downloads and information on rights, acknowledgement and usage are available here.
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Current Protocols

database

Provider: John Wiley & Sons
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Descriptions: Users have access to the following laboratory protocols via the TMC Library:


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Allen Brain Atlas

database

Provider: Allen Institute for Brain Science
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Descriptions: "A growing collection of online public resources integrating extensive gene expression and neuroanatomical data, complete with a novel suite of search and viewing tools." Images and gene expression data are available for the mouse brain and spinal cord, and human and non-human primate brains. Excellent video tutorials  provide training in the use of the atlases and the Brain Explorer 2 software.
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1000 Genomes

database

Provider: 1000 Genomes
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Descriptions: 1000 Genomes: a deep catalog of human genetic variation "...is the first project to sequence the genomes of a large number of people, to provide a comprehensive resource on human genetic variation... The goal of the 1000 Genomes Project is to find most genetic variants that have frequencies of at least 1% in the populations studied." 1000 Genomes is an international endeavor, with participants from institutes, governments and universities world-wide. "DNA from the samples will be available for researchers to follow up with more detailed studies of variation in particular regions. The cell lines will allow researches to study cellular phenotypes such as gene expression, epigenetic patterns, and drug response. The extensive genotype data available on the samples, and the trio samples for some of the populations, will allow researchers to map regions of the genome computationally that affect the cellular phenotypes, and to study the heritability of these phenotypes."
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