uScience is a new pilot repository of classroom-tested and peer-reviewed instructional resources for undergraduate-level science courses, to be focused primarily on human health issues. The uScience site is an expansion of MedEdPORTAL that facilitates faculty experimentation with new instructional strategies. Each resource found in the uScience collection is a complete learning unit, including activities, presentation, data, resources, instructor guide and with some, assessment. Each resource is peer-reviewed for content and instructional effectiveness. The first resources made available include units in cellular and molecular biology, anatomy and physiology, evolutionary biology, chemistry and physics.